For chemists and researchers engaged in organic synthesis, a thorough understanding of a reagent's properties is fundamental to its successful application. N,N'-Bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine (CAS: 152120-55-3) is a compound whose specific chemical and physical characteristics make it a valuable asset in various synthetic processes, particularly as a condensation reagent.

Chemical Identity and Structure

N,N'-Bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine, with the molecular formula C20H18N4O4 and a molecular weight of approximately 378.38 g/mol, is a heterocyclic organic compound. The presence of the pyrazole ring, coupled with the benzyloxycarbonyl (Cbz) protecting groups on the carboxamidine moiety, imbues it with specific reactivity. These Cbz groups are often employed to protect amine functionalities and can be removed under specific conditions, allowing for further chemical transformations.

Physical Characteristics and Specifications

In its pure form, this compound typically presents as an off-white to white crystalline powder. This appearance is a standard specification that buyers should verify. Key physical properties include:

  • Purity: Generally specified as ≥98.0% by HPLC, indicating a high level of the desired compound and minimal impurities, crucial for predictable reaction outcomes.
  • Melting Point: Typically reported in the range of 90-96°C. This property is vital for solid-state characterization and can indicate purity. A sharp melting range usually signifies a purer substance.
  • Solubility: While specific solubility data may vary, such organic compounds are generally soluble in common organic solvents like dichloromethane, chloroform, ethyl acetate, and possibly less soluble in alcohols or water.
  • Stability: When stored correctly, typically in a cool, dry, and well-sealed container away from oxidizing agents, it maintains its stability.

Applications and Functional Role

The primary application of N,N'-Bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine is as a condensation reagent. In this capacity, it facilitates the formation of new covalent bonds between molecules, a fundamental process in organic synthesis. This is particularly useful in the creation of complex structures found in pharmaceutical intermediates and other fine chemicals. Its specific reactivity profile allows for controlled reactions, minimizing unwanted side products.

Sourcing and Reliability for R&D Scientists

For R&D scientists looking to buy this compound, sourcing from reliable manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. in China is a strategic advantage. These suppliers ensure that the compound meets stringent quality standards, providing detailed specifications and consistent batch quality. When purchasing, scientists should always request the latest COA and MSDS (Material Safety Data Sheet) to understand handling precautions and detailed analytical data. The availability of this reagent from reputable sources facilitates uninterrupted research and development activities.

In conclusion, N,N'-Bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine is a well-defined chemical entity with specific properties that make it an effective condensation reagent. Understanding these characteristics is key for its optimal application in organic synthesis and for selecting dependable suppliers who can guarantee quality and consistency.