The field of organic chemistry is continuously enriched by compounds that offer unique reactive capabilities and enable the creation of complex molecular architectures. 2-Fluoroacetophenone (CAS 450-95-3) is one such compound, valued for its role in synthetic chemistry, particularly in the realm of fluorinated molecules. This article explores its chemical properties, common synthesis routes, and diverse applications, offering insights for chemists and procurement specialists looking to buy this valuable reagent.

2-Fluoroacetophenone, characterized as an off-white solid, possesses a molecular structure that makes it highly amenable to various chemical transformations. The presence of a phenyl ketone moiety alongside a fluoroacetyl group provides distinct reactivity. Chemically, it can undergo reactions characteristic of ketones, such as nucleophilic addition, while the alpha-fluorine atom can be leveraged in specific substitution or elimination reactions, or even influence the acidity of adjacent protons. This versatility makes it an attractive starting material for synthesizing a wide array of fluorinated organic compounds.

A common method for synthesizing 2-Fluoroacetophenone involves the reaction of fluoroacetonitrile with benzene under Friedel-Crafts acylation conditions, or through the direct fluorination of acetophenone derivatives. For industrial-scale production, manufacturers optimize these processes to ensure high yield and purity, often achieving NLT 98% for CAS 450-95-3. As a leading manufacturer from China, we leverage advanced synthesis techniques to provide a consistent supply of this crucial intermediate.

The applications of 2-Fluoroacetophenone are diverse. Its most prominent use is in the synthesis of fluorinated ketones, which are precursors to pharmaceuticals, agrochemicals, and specialty materials. For instance, it can be employed in the preparation of certain anti-cancer agents or as a building block for novel pesticides. Researchers also utilize it in studies exploring new carbon-fluorine bond forming methodologies. Understanding these applications helps R&D scientists identify its potential value in their own projects.

For companies in need of 2-Fluoroacetophenone, partnering with a reliable supplier is essential. We, as a dedicated manufacturer in China, offer competitive pricing and a steadfast commitment to quality. Our aim is to empower chemists and researchers by providing them with the high-purity intermediates necessary for their groundbreaking work. When you are ready to purchase CAS 450-95-3, consider our expertise and manufacturing capabilities to ensure the success of your synthetic endeavors.