At NINGBO INNO PHARMCHEM CO.,LTD., we specialize in providing high-quality chemical intermediates, and 2-aminopropanediamide (CAS: 62009-47-6) stands out for its critical role in pharmaceutical synthesis. This article delves into the chemical aspects of this compound, from its synthesis methods to its defining properties, which make it indispensable for drug developers.

The synthesis of 2-aminopropanediamide typically involves the ammonolysis of diethyl aminomalonate hydrochloride. This process, often carried out in methanol with a 25% ammonia solution, leads to the formation of 2-aminopropanediamide as a white powder. The careful control of reaction conditions, such as temperature and reaction time, is essential to achieve optimal yields and purity, which are critical factors for its subsequent use in drug manufacturing. Research has explored modifications to these methods to enhance efficiency and sustainability, aligning with the principles of green chemistry.

The physical and chemical properties of 2-aminopropanediamide are well-documented and are crucial for its application as a pharmaceutical intermediate. Its appearance as a light yellow solid powder is a primary identifier. Furthermore, its purity is typically specified as ≥98.0%, with stringent limits on water content (≤1.0%) and residue on ignition (≤0.1%). These specifications ensure that the intermediate is suitable for use in sensitive pharmaceutical processes where even minor impurities can affect the final product's efficacy and safety.

The significance of 2-aminopropanediamide is most notably recognized in its use as an intermediate for Favipiravir (CAS: 259793-96-9). Favipiravir is an antiviral drug that has demonstrated effectiveness against a range of RNA viruses. The demand for reliable and high-purity 2-aminopropanediamide is directly linked to the global need for such antiviral treatments. Pharmaceutical companies looking to buy 2-aminopropanediamide are seeking suppliers who can consistently deliver material meeting these rigorous standards.

Moreover, 2-aminopropanediamide serves as a building block for creating structural analogs of pyrazine-based antiviral compounds. This research is vital for discovering next-generation therapeutics with enhanced properties. The ability to fine-tune the synthesis and explore derivatives of 2-aminopropanediamide opens new avenues for drug discovery and development, addressing unmet medical needs.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to supplying high-quality 2-aminopropanediamide that meets the demanding requirements of the pharmaceutical industry. Our consistent quality and reliable supply chain support researchers and manufacturers in their pursuit of effective antiviral therapies. For detailed technical information, including COA and MSDS, or to inquire about purchasing 2-aminopropanediamide, please contact us.