In the realm of chemical synthesis and life sciences, understanding the fundamental physicochemical properties of key compounds is paramount for successful application development. 1-Palmitoyl-2-Oleoyl-sn-glycero-3-phosphoethanolamine (POPE) is a phospholipid that exemplifies this principle, possessing unique characteristics that make it invaluable across various scientific disciplines, particularly in membrane biophysics and drug delivery systems. For researchers and procurement specialists seeking this compound, a detailed understanding of its properties and the availability of high-quality sources are essential.

POPE is a phospholipid characterized by a specific fatty acid composition: a saturated palmitic acid (C16:0) at the sn-1 position and an unsaturated oleic acid (C18:1 cis-9) at the sn-2 position of the glycerol backbone. This asymmetric and unsaturated fatty acid profile significantly influences its behavior in aqueous environments. Unlike saturated phospholipids that tend to pack into rigid lamellar structures, the cis double bond in oleic acid introduces kinks, which reduces van der Waals interactions between adjacent lipid molecules. This leads to lower melting points and increased fluidity of the lipid bilayer.

One of the most significant physicochemical properties of POPE is its ability to form non-bilayer phases, specifically the inverse hexagonal (HII) phase, at temperatures above its chain-melting transition. This tendency is attributed to the relatively small headgroup of phosphatidylethanolamine compared to its bulky hydrophobic tails, which creates a cone-like shape. This property is crucial for applications involving membrane fusion, such as in cellular processes or in the design of liposomes intended for enhanced cellular uptake or intracellular drug release. Researchers actively investigate these phase behaviors, often searching for “POPE phase transitions” or “POPE inverse hexagonal phase” to understand its utility.

For effective use in drug delivery systems, POPE is often formulated with other lipids, like POPC (1-Palmitoyl-2-Oleoyl-sn-glycero-3-phosphocholine), to achieve desired liposome stability and membrane properties. The precise ratio of these lipids can control the overall fluidity, permeability, and the ability of the liposome to interact with biological membranes. Procurement managers looking to buy POPE must prioritize suppliers who can guarantee purity and consistency in this fatty acid composition. Companies like NINGBO INNO PHARMCHEM CO.,LTD., a prominent manufacturer and supplier, offer POPE with stringent quality controls and high purity levels (>98%).

Understanding the solubility of POPE in various solvents is also key for formulation. It is typically soluble in chloroform and methanol mixtures, allowing for preparation of lipid dispersions. The stability of POPE, particularly its susceptibility to oxidation due to the unsaturated oleic acid chain, also necessitates proper storage conditions, usually at low temperatures (-20°C) under an inert atmosphere, as recommended by reputable suppliers. For bulk purchases, obtaining competitive POPE prices from reliable Chinese manufacturers can significantly reduce project costs.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing researchers and formulators with access to high-quality POPE, backed by detailed technical specifications and reliable supply. By understanding the fundamental physicochemical properties of POPE, you can effectively leverage its capabilities in your advanced research and product development. We invite you to contact us to learn more about our POPE products and to discuss how we can support your scientific objectives. Secure a trusted source for your critical phospholipid needs today.