2-Amino-5-fluorobenzonitrile (CAS 61272-77-3) is a molecular entity that has garnered significant attention in the chemical research community due to its versatile reactivity and extensive applications, particularly as an intermediate in organic synthesis. This compound, characterized by its off-white to grey crystalline powder appearance, possesses a molecular formula of C7H5FN2 and a molecular weight of 136.13 g/mol. Its melting point typically ranges between 92-96°C, and it exhibits a boiling point of approximately 275.5°C at 760 mmHg.

The primary utility of 2-Amino-5-fluorobenzonitrile lies in its role as a precursor for a wide array of chemical compounds. Its structure is particularly amenable to reactions that form heterocyclic rings, which are fundamental motifs in many biologically active molecules and advanced materials. The ortho-arrangement of the amino and nitrile groups on the benzonitrile core makes it an excellent starting material for Friedländer reactions and similar condensation processes, leading to valuable quinazoline and tacrine derivatives.

Researchers often seek efficient 2-Amino-5-fluorobenzonitrile synthesis routes to ensure a consistent and high-quality supply for their work. One common synthetic approach involves the reduction of nitro precursor, a method that has been refined over time to maximize yield and purity. The strategic use of this compound allows chemists to incorporate specific functionalities and structural elements into their target molecules, making it indispensable in fields like medicinal chemistry and materials science.

Furthermore, the presence of the fluorine atom adds another dimension to its utility. Fluorine substitution can significantly alter a molecule's pharmacokinetic properties, such as lipophilicity and metabolic stability, which are crucial considerations in drug design. As NINGBO INNO PHARMCHEM CO.,LTD. continues to support innovation in chemical sciences, we recognize 2-Amino-5-fluorobenzonitrile as a cornerstone intermediate, enabling the creation of novel compounds that address critical challenges in health and technology.