2'-Fluoroacetophenone, identified by its CAS number 445-27-2, is a compound of significant interest in the realm of organic chemistry. As a fine chemical intermediate, it possesses a unique combination of properties that make it indispensable for various synthetic endeavors. This article will explore its chemical characteristics, common synthesis routes, and its wide-ranging applications, highlighting why it is a go-to compound for researchers and industrial chemists alike.

At its core, 2'-Fluoroacetophenone is an aromatic ketone with the molecular formula C8H7FO and a molecular weight of approximately 138.14. Its physical state is typically described as a clear, colorless to light yellow liquid. Key physical properties include a melting point of around 26-27°C and a boiling point between 187-189°C. These parameters are crucial for its handling and use in various chemical reactions. The presence of the fluorine atom at the ortho position influences its electronic properties and reactivity, making it a valuable building block for creating more complex fluorinated organic molecules.

The synthesis of 2'-Fluoroacetophenone can be achieved through several established chemical pathways. One common method involves the Friedel-Crafts acylation of fluorobenzene. Another approach might involve the oxidation of a corresponding alcohol or the reaction of an organometallic reagent with a suitable acylating agent. The efficiency and purity of the 2'-Fluoroacetophenone manufacturing process are critical factors for its industrial application, ensuring that the final product meets the high standards required by industries such as pharmaceuticals and specialty chemicals. NINGBO INNO PHARMCHEM CO.,LTD. is one of the manufacturers known for producing this compound.

The applications of 2'-Fluoroacetophenone are diverse and span across several scientific and industrial sectors. It serves as a vital intermediate in the synthesis of a wide array of organic compounds, including pharmaceuticals, agrochemicals, and materials for electronics. Its ability to readily undergo various reactions, such as nucleophilic addition, condensation, and cyclization, makes it a versatile tool for chemists designing new molecules. The demand for 2'-Fluoroacetophenone as a synthesis intermediate underscores its importance in advancing chemical innovation.

For those looking to procure this chemical, understanding where to buy 2'-Fluoroacetophenone and ensuring its quality is essential. Reputable suppliers provide detailed specifications and certifications, guaranteeing the purity and authenticity of the product. Whether for laboratory research or large-scale industrial production, 2'-Fluoroacetophenone remains a key compound that enables groundbreaking advancements in chemistry and related fields.