4-Fluorophenylacetonitrile, also known as p-Fluorobenzyl cyanide and identified by CAS number 459-22-3, is a chemical compound of significant interest across multiple industrial sectors, primarily due to its utility as a versatile intermediate in organic synthesis. As a fluorinated organic nitrile, it possesses a unique combination of reactivity and properties that make it a valuable building block for complex molecules.

Chemically, 4-Fluorophenylacetonitrile (C8H6FN) has a molecular weight of 135.14 g/mol. Its appearance is typically described as a colorless to pale yellow liquid, with a purity of ≥98% (GC). The presence of the fluorine atom imparts specific electronic and steric effects that influence its reactivity and the properties of the compounds derived from it. The nitrile group (-CN) is a highly versatile functional group that can undergo various transformations, including hydrolysis to carboxylic acids, reduction to amines, and nucleophilic addition reactions. These characteristics make it an excellent starting material for creating a wide range of organic compounds.

The synthesis of 4-Fluorophenylacetonitrile generally involves reactions that introduce the cyano group onto a fluorinated benzyl moiety. While specific proprietary methods may vary among manufacturers, common approaches might involve nucleophilic substitution reactions using a fluoride source and a cyanide salt on a suitable precursor. For industrial-scale production, factors such as yield optimization, cost-effectiveness, and environmental impact are critical considerations for any reputable manufacturer of 4-Fluorophenylacetonitrile.

The applications of 4-Fluorophenylacetonitrile are diverse and impactful. In the pharmaceutical industry, it serves as a crucial intermediate in the synthesis of various APIs, including certain antidepressants and antihistamines. The fluorine atom enhances drug bioavailability and metabolic stability, making it a preferred choice for drug designers. Therefore, pharmaceutical R&D scientists often look to purchase CAS 459-22-3 to facilitate their drug discovery programs.

In the agrochemical sector, 4-Fluorophenylacetonitrile is employed as a building block for herbicides and other crop protection agents. Its incorporation into these molecules can enhance their efficacy and environmental persistence. For companies looking to buy 4-Fluorophenylacetonitrile for these applications, sourcing from a reliable supplier in China ensures access to high-quality material at competitive 4-Fluorophenylacetonitrile prices.

Furthermore, this compound finds utility in material science, particularly in the development of liquid crystals and specialized polymers, where its unique fluorinated structure can impart desirable physical properties such as thermal stability and specific optical characteristics.

For procurement managers and research scientists, understanding the specifications and sourcing options for 4-Fluorophenylacetonitrile (CAS 459-22-3) is essential. Partnering with established chemical suppliers that offer consistent quality, competitive pricing, and robust supply chains is key to successful project execution. Whether for pharmaceutical synthesis, agrochemical development, or advanced materials, 4-Fluorophenylacetonitrile remains a cornerstone intermediate.