1-Bromo-3,5-difluorobenzene (CAS 461-96-1) is a chemical intermediate of significant interest in various synthesis applications, particularly within the pharmaceutical and agrochemical sectors. Understanding its synthesis pathways and proper handling procedures is crucial for chemists and procurement specialists. As a reliable manufacturer, we aim to provide insights into this valuable compound.

The synthesis of 1-Bromo-3,5-difluorobenzene typically involves electrophilic aromatic substitution reactions. A common method is the bromination of 3,5-difluorobenzene using a bromine source like elemental bromine or N-bromosuccinimide (NBS) in the presence of a Lewis acid catalyst such as iron(III) bromide or aluminum bromide. The reaction conditions, including temperature and catalyst concentration, are optimized to ensure regioselectivity and high yields. Another route involves the fluorination of a suitable brominated precursor. For instance, reacting 1-bromo-3,5-dichlorobenzene with a fluoride salt under specific catalytic conditions can also yield the desired difluorinated product.

Handling 1-Bromo-3,5-difluorobenzene requires adherence to standard laboratory safety protocols. The compound is typically a clear, colorless to light yellow liquid with a boiling point around 140°C. It is important to store it in a dry, well-ventilated warehouse, away from direct sunlight, heat, and moisture, as recommended by storage guidelines. Personal protective equipment, including gloves, safety glasses, and lab coats, should always be worn when handling the chemical to prevent skin or eye contact.

For researchers and manufacturers looking to buy 1-bromo-3,5-difluorobenzene high purity, securing a dependable supply is paramount. As a leading 1-bromo-3,5-difluorobenzene pharmaceutical intermediate manufacturer and cas 461-96-1 supplier in China, we ensure that our product meets stringent quality standards (≥99.0% assay). Understanding the competitive 3,5-difluorobromobenzene price is important, but should be balanced with the assurance of quality and consistent supply. If you are asking where to purchase organic synthesis intermediates, consider established manufacturers who can provide detailed technical data sheets and safety information.