Exploring the Synthesis and Properties of Amino-PEG2-t-butyl Ester
Amino-PEG2-t-butyl ester, more formally known as Tert-butyl 3-(2-(2-aminoethoxy)ethoxy)propanoate (CAS: 756525-95-8), is a critical bifunctional molecule that has garnered significant attention in synthetic chemistry. This compound, with a molecular formula of C11H23NO4 and a molecular weight of 233.30500, offers a unique structural motif that combines a protected amine and a protected carboxylic acid, linked by a short polyethylene glycol (PEG) chain. This combination makes it an exceptionally useful reagent for a wide range of chemical modifications and elaborations.
The synthesis of such bifunctional molecules often involves careful protection and deprotection strategies. While specific details of its industrial synthesis are proprietary, the general approach would typically involve reactions that precisely couple the desired ethylene glycol units, followed by functional group modifications to introduce the terminal amine and the tert-butyl ester. The resulting product is then purified to achieve a high purity level, often exceeding 97%, which is crucial for its applications in sensitive research areas, including pharmaceutical synthesis. Sourcing this high-purity intermediate from established chemical intermediates suppliers in China ensures consistent quality and reliable performance.
The properties of Amino-PEG2-t-butyl ester, such as its solubility and reactivity, are dictated by its structure. The PEG chain can improve water solubility and biocompatibility, making it suitable for bioconjugation and drug delivery systems. The tert-butyl ester provides a stable protecting group for the carboxylic acid, which can be selectively removed under acidic conditions, revealing the free acid for further reactions. The terminal amine group is also readily available for reactions such as acylation, alkylation, or amide bond formation. Understanding these properties is key for chemists aiming to buy and utilize this versatile compound in their research, whether it's for developing new materials, complex organic molecules, or as a linker in advanced therapeutic modalities. Its importance in chemical research underscores the need for reliable suppliers who can provide this compound with guaranteed purity and specifications.
The synthesis of such bifunctional molecules often involves careful protection and deprotection strategies. While specific details of its industrial synthesis are proprietary, the general approach would typically involve reactions that precisely couple the desired ethylene glycol units, followed by functional group modifications to introduce the terminal amine and the tert-butyl ester. The resulting product is then purified to achieve a high purity level, often exceeding 97%, which is crucial for its applications in sensitive research areas, including pharmaceutical synthesis. Sourcing this high-purity intermediate from established chemical intermediates suppliers in China ensures consistent quality and reliable performance.
The properties of Amino-PEG2-t-butyl ester, such as its solubility and reactivity, are dictated by its structure. The PEG chain can improve water solubility and biocompatibility, making it suitable for bioconjugation and drug delivery systems. The tert-butyl ester provides a stable protecting group for the carboxylic acid, which can be selectively removed under acidic conditions, revealing the free acid for further reactions. The terminal amine group is also readily available for reactions such as acylation, alkylation, or amide bond formation. Understanding these properties is key for chemists aiming to buy and utilize this versatile compound in their research, whether it's for developing new materials, complex organic molecules, or as a linker in advanced therapeutic modalities. Its importance in chemical research underscores the need for reliable suppliers who can provide this compound with guaranteed purity and specifications.
Perspectives & Insights
Alpha Spark Labs
“30500, offers a unique structural motif that combines a protected amine and a protected carboxylic acid, linked by a short polyethylene glycol (PEG) chain.”
Future Pioneer 88
“This combination makes it an exceptionally useful reagent for a wide range of chemical modifications and elaborations.”
Core Explorer Pro
“The synthesis of such bifunctional molecules often involves careful protection and deprotection strategies.”