Understanding the synthesis and intrinsic properties of chemical intermediates is fundamental for their effective utilization in research and industrial applications. N-Boc-L-tert-Leucine (CAS 62965-35-9), a protected amino acid, is no exception. NINGBO INNO PHARMCHEM CO.,LTD. provides insights into the common synthetic routes and key characteristics that make this compound a valuable asset in organic chemistry and pharmaceutical development.

The synthesis of N-Boc-L-tert-Leucine typically involves the protection of the amino group of L-tert-leucine using a tert-butoxycarbonyl (Boc) protecting group. A widely employed method involves reacting L-tert-leucine with di-tert-butyl dicarbonate (Boc anhydride) in the presence of a base, such as triethylamine, often in a solvent like methanol or a mixture of organic solvents and water. The reaction is usually carried out at controlled temperatures, often starting at 0-5°C and then allowing it to proceed at room temperature. After the reaction is complete, standard work-up procedures are employed, which may include extraction, washing with acidic solutions to remove excess base, drying of the organic layer, and solvent evaporation to yield the crude product. Further purification, such as recrystallization, might be performed to achieve the desired purity.

The resulting N-Boc-L-tert-Leucine is characterized by several key physical and chemical properties that dictate its utility. It typically presents as a white crystalline powder with a melting point in the range of 85-90°C or slightly higher depending on the source and purity. Its molecular formula is C11H21NO4, with a molecular weight of approximately 231.29 g/mol. Crucially, for pharmaceutical applications, N-Boc-L-tert-Leucine exhibits high purity, often specified as ≥ 98% by HPLC, and maintains high enantiomeric purity (≥ 99% ee for the L-enantiomer). This high degree of purity and stereochemical integrity is essential for its role as a building block in drug synthesis.

The solubility profile of N-Boc-L-tert-Leucine is also noteworthy. It is generally soluble in polar organic solvents like DMF and DMSO, and slightly soluble in water. This solubility characteristic is important for designing reaction conditions and for purification processes. Storage recommendations typically advise keeping the compound at 2-8°C under an inert atmosphere to maintain its stability and prevent degradation, especially for long-term storage.

For researchers and manufacturers looking to buy N-Boc-L-tert-Leucine, understanding these synthesis pathways and properties helps in selecting the right product and optimizing its use. NINGBO INNO PHARMCHEM CO.,LTD. ensures that our N-Boc-L-tert-Leucine meets these critical specifications, providing a reliable source for your synthetic chemistry needs. Our expertise in chemical manufacturing allows us to deliver consistent quality, supporting advancements in drug discovery and material science.