The pharmaceutical industry's demand for high-purity, stereochemically defined intermediates is continuously growing. (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine, known by CAS numbers 130018-88-1 and 300543-56-0, is a prime example of such a crucial compound. It serves as an indispensable intermediate in the synthesis of levocetirizine, a widely prescribed non-sedating antihistamine used to treat various allergic conditions. The production of levocetirizine hinges on the availability of this precisely structured piperazine derivative, highlighting its significance in modern medicine.

The Chemical Foundation: Properties and Purity

(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine is typically presented as an off-white solid, a visual indicator of its refined state. Its molecular formula, C17H19ClN2, and a molecular weight around 286.80 g/mol, provide the structural basis for its role in API synthesis. For pharmaceutical manufacturers, the purity of this intermediate is paramount, often exceeding 98.0%. This high purity ensures that downstream reactions proceed efficiently and that the final levocetirizine product meets stringent regulatory standards for safety and efficacy. The compound’s specific chirality is also critical; as the precursor for the R-enantiomer of cetirizine, maintaining this stereochemical integrity throughout the synthesis is essential.

The market for such intermediates is competitive, with many manufacturers worldwide striving to meet the demand. For companies looking to buy (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine, securing a reliable supply from a trusted source is key. This involves evaluating potential suppliers based on their manufacturing capabilities, quality control processes, and adherence to industry standards. Identifying a proficient (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine manufacturer specializing in chiral synthesis is vital for success.

The Role of Chinese Manufacturers in the Supply Chain

China has become a dominant force in the global chemical manufacturing sector, offering substantial advantages in production capacity, technological innovation, and cost-effectiveness. Consequently, many pharmaceutical companies source critical intermediates like (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine from Chinese suppliers. A leading levocetirizine intermediate supplier from China can provide assurance of quality, often backed by advanced analytical laboratories and robust quality management systems. When exploring the price of chlorobenzhydryl piperazine, it's important to consider the comprehensive value proposition offered by these suppliers, which includes not just cost but also reliability and regulatory compliance.

The process of synthesizing CAS 300543-56-0 is complex, and manufacturers who have mastered its efficient and high-purity production are highly valued. Pharmaceutical companies seeking to purchase pharmaceutical intermediate should conduct thorough due diligence, ensuring their chosen supplier can consistently deliver material that meets exact specifications, batch after batch. This consistency is fundamental to maintaining the integrity of the levocetirizine production process.

Strategic Sourcing for Pharmaceutical Excellence

The ability to secure a stable and high-quality supply of (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine directly impacts a pharmaceutical company’s ability to meet market demand for levocetirizine. Building strong partnerships with reputable manufacturers allows for proactive management of supply chain risks and ensures that production lines remain uninterrupted. Whether you are looking to order (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine for established large-scale production or for niche applications, selecting a supplier committed to excellence in both product quality and service is paramount. This strategic approach to sourcing intermediates is a hallmark of successful pharmaceutical operations.