The intricate world of organic synthesis relies heavily on versatile intermediates that offer multiple avenues for molecular construction. 4-Bromo-2-(trifluoromethyl)benzonitrile (CAS: 191165-13-6) is a prime example, serving as a foundational component for numerous complex molecules, particularly in the pharmaceutical and agrochemical sectors. Its strategic combination of a nitrile group, a bromine atom, and a trifluoromethyl substituent makes it a highly valuable building block for chemists worldwide.

One of the most common and powerful applications of 4-Bromo-2-(trifluoromethyl)benzonitrile involves its participation in palladium-catalyzed cross-coupling reactions. The aryl bromide functionality readily undergoes reactions like Suzuki-Miyaura coupling with boronic acids, Stille coupling with organostannanes, or Heck reactions with alkenes. These reactions are instrumental in forming new carbon-carbon bonds, allowing for the efficient assembly of diverse aromatic and heteroaromatic systems. For R&D scientists looking to synthesize novel compounds, understanding how to buy and utilize this intermediate in such reactions is crucial.

The nitrile group (-C≡N) on the benzonitrile ring provides another versatile handle for further transformations. It can be hydrolyzed to a carboxylic acid, reduced to an amine, or reacted with Grignard reagents to form ketones, among other possibilities. This inherent reactivity allows for the introduction of various functional groups, tailoring the properties of the final product for specific applications. Pharmaceutical chemists, for instance, can transform the nitrile into an amide or amine to influence drug-receptor interactions or solubility profiles.

The trifluoromethyl (-CF3) group is a key feature that imparts unique properties. It is known for its strong electron-withdrawing effect, influencing the reactivity of the aromatic ring, and its lipophilicity, which can enhance the membrane permeability and metabolic stability of derived compounds. These characteristics are highly desirable in both drug design and agrochemical formulation, where improved efficacy and longevity are often sought. As a leading supplier, we ensure this critical group is present in high purity in our product.

For professionals aiming to procure this essential intermediate, partnering with a reliable manufacturer in China like us is recommended. We offer competitive price points and ensure the consistent quality of 4-Bromo-2-(trifluoromethyl)benzonitrile, guaranteeing purity of ≥98.0%. Whether you are developing new APIs or advanced agrochemicals, this compound offers a robust platform for synthetic exploration and production. We encourage you to inquire about bulk purchases and explore how our offerings can support your chemical synthesis needs.