Fine Chemical Synthesis with 3-Bromo-2-chloro-5-(trifluoromethyl)pyridine
The field of fine chemical synthesis is driven by the development of specialized molecules that serve as building blocks for a vast array of advanced products, from pharmaceuticals and agrochemicals to electronic materials and performance chemicals. Among these critical intermediates, heterocyclic compounds, particularly those incorporating fluorine, have gained significant prominence due to their unique reactivity and the desirable properties they impart to final products. 3-Bromo-2-chloro-5-(trifluoromethyl)pyridine (CAS: 71701-92-3) stands out as a prime example of such a versatile molecule.
This compound features a pyridine core functionalized with a trifluoromethyl group, a bromine atom, and a chlorine atom. This specific arrangement of functional groups makes it an exceptionally useful intermediate in organic synthesis. The trifluoromethyl group (-CF3) is known to enhance lipophilicity, metabolic stability, and binding affinity in biologically active molecules, making it a popular choice in medicinal chemistry. The bromine and chlorine atoms act as reactive handles, readily participating in various cross-coupling reactions. These reactions, often catalyzed by transition metals like palladium, allow for the precise introduction of carbon-carbon or carbon-heteroatom bonds, enabling chemists to construct complex molecular architectures with high efficiency and selectivity.
For instance, researchers in the fine chemical sector might utilize 3-Bromo-2-chloro-5-(trifluoromethyl)pyridine in the synthesis of novel ligands for catalysis, advanced materials for optoelectronics, or even as a precursor for specialized polymers. Its well-defined reactivity allows for its incorporation into diverse synthetic pathways, making it a sought-after reagent for custom synthesis projects. The typical purity of this compound, often exceeding 95%, ensures reliable and reproducible experimental outcomes, which is critical in fine chemical manufacturing.
When procuring such specialized intermediates, it is essential to engage with reputable manufacturers and suppliers. Companies that offer 3-Bromo-2-chloro-5-(trifluoromethyl)pyridine often provide detailed product specifications, including CAS number (71701-92-3), molecular formula (C6H2BrClF3N), and physical characteristics such as its pale yellow to pale brown solid appearance. Manufacturers based in China are particularly known for their competitive pricing and ability to supply materials in various quantities, from research-scale grams to industrial-scale kilograms. It is always advisable to request quotes and free samples to ensure the material meets your exact needs.
In summary, 3-Bromo-2-chloro-5-(trifluoromethyl)pyridine is a foundational intermediate in modern fine chemical synthesis. Its unique combination of a trifluoromethyl group and reactive halogen substituents makes it indispensable for creating complex and high-value chemical products. Partnering with expert chemical suppliers is key to leveraging its full potential in your synthetic endeavors.
Perspectives & Insights
Future Origin 2025
“This compound features a pyridine core functionalized with a trifluoromethyl group, a bromine atom, and a chlorine atom.”
Core Analyst 01
“This specific arrangement of functional groups makes it an exceptionally useful intermediate in organic synthesis.”
Silicon Seeker One
“The trifluoromethyl group (-CF3) is known to enhance lipophilicity, metabolic stability, and binding affinity in biologically active molecules, making it a popular choice in medicinal chemistry.”