Fluorinated organic compounds, particularly those incorporating benzonitrile and trifluoromethyl groups, are invaluable in modern chemistry. Their unique electronic properties and metabolic stability make them highly sought after in pharmaceuticals, agrochemicals, and material science. Among these, 3-Hydroxy-4-(Trifluoromethyl)Benzonitrile (CAS 731002-50-9) stands out as a key intermediate. As a seasoned manufacturer, we want to highlight its importance and provide guidance on sourcing this critical compound.

The Chemistry of 3-Hydroxy-4-(Trifluoromethyl)Benzonitrile

This compound, typically appearing as a white to off-white solid with a melting point of 188-189°C, combines three crucial functional elements: a nitrile group (-CN), a hydroxyl group (-OH), and a trifluoromethyl group (-CF3). The trifluoromethyl group imparts lipophilicity and can significantly influence the electronic properties and metabolic stability of molecules derived from it. The hydroxyl group offers a site for further functionalization, while the nitrile can be transformed into various other nitrogen-containing functionalities. This makes 3-Hydroxy-4-(Trifluoromethyl)Benzonitrile a versatile building block for complex organic syntheses.

Its most recognized application is as an intermediate in the synthesis of Monepantel, a crucial drug in veterinary parasitology. Beyond this, its structural features make it attractive for research into new drug candidates, specialized polymers, and electronic materials.

Key Considerations for Sourcing Fluorinated Intermediates

When you need to buy 3-Hydroxy-4-(Trifluoromethyl)Benzonitrile, especially for demanding applications, several factors are critical:

  • Purity and Consistency: Look for suppliers who guarantee high purity (e.g., >98%) and provide detailed impurity profiles. Consistency across batches is vital for reproducible results in synthesis.
  • Technical Specifications: Ensure the product meets your specific needs regarding physical form (solid), melting point, and any other relevant parameters.
  • Manufacturer Reliability: Procuring directly from a specialized manufacturer ensures better control over quality, supply chain, and often, more competitive price. Certifications like ISO 9001 are indicative of a robust quality management system.
  • Custom Synthesis Capabilities: If your project requires specific modifications or unique specifications, partnering with a manufacturer offering custom synthesis services is advantageous.
  • Supply Chain Security: As a global supplier in China, we understand the importance of a secure and stable supply chain for critical intermediates like this.

Applications Driving Demand

The demand for 3-Hydroxy-4-(Trifluoromethyl)Benzonitrile is driven by its utility in creating molecules with enhanced properties. In pharmaceutical research, the introduction of trifluoromethyl groups can improve a drug's efficacy, bioavailability, and half-life. For scientists and formulators looking for reliable chemical reagents, understanding the synthesis pathway and sourcing from expert manufacturers is key to success.

We are dedicated to providing high-quality fluorinated benzonitriles and other advanced intermediates. We invite you to reach out for a quote or to discuss your specific project needs. Our team is ready to support your research and manufacturing endeavors with exceptional chemical solutions.