The intricate world of peptide synthesis relies on precision-engineered building blocks, and Fmoc-Asn(Trt)-Wang Resin is a prime example. This specialized resin is indispensable for the incorporation of L-asparagine into peptide chains during Solid Phase Peptide Synthesis (SPPS). Its robust design ensures efficient coupling and clean cleavage, making it a preferred choice for researchers and manufacturers alike. Understanding its specifications and sourcing options is key to optimizing peptide production.

At its core, Fmoc-Asn(Trt)-Wang Resin is a polystyrene support functionalized with a Wang linker, pre-loaded with Nα-Fmoc-Nγ-trityl-L-asparagine. The Nα-Fmoc group allows for sequential elongation of the peptide chain using base-labile deprotection, while the Nγ-trityl group provides essential protection for the asparagine side-chain amide. This dual protection strategy is vital to prevent side reactions such as aspartimide formation or dehydration, which can compromise peptide purity and yield. When you buy Fmoc-Asn(Trt)-Wang resin, these protective groups are already in place, streamlining the synthesis process.

Key specifications to consider when sourcing this resin include the loading capacity, typically ranging from 0.3 to 0.8 mmol/g, and the particle size, commonly 100-200 or 200-400 mesh. These parameters influence the efficiency of solvent diffusion and reagent access to the reactive sites during synthesis. A higher loading capacity means more peptide can be synthesized from a given mass of resin, potentially reducing costs for large-scale production. For procurement managers, identifying a reliable Fmoc-Asn(Trt)-Wang resin manufacturer in China can be advantageous due to competitive pricing and manufacturing capabilities.

When seeking to purchase Fmoc-Asn(Trt)-Wang resin, obtaining a detailed Fmoc-Asn(Trt)-Wang resin price quote is a crucial step. This quote should not only reflect the quantity but also the quality and purity of the resin. A reputable Fmoc-Asn(Trt)-Wang resin supplier will provide comprehensive technical data, including Certificates of Analysis (CoA), detailing the resin's specifications and quality control measures. This due diligence ensures that the resin will perform reliably in your synthesis protocols, whether for research purposes or commercial production of peptide-based pharmaceuticals or other fine chemicals.

Effective use of Fmoc-Asn(Trt)-Wang Resin involves standard SPPS protocols. The Fmoc group is removed using piperidine, and subsequent amino acids are coupled using standard peptide coupling reagents. The final peptide is cleaved from the resin using a strong acid cocktail, typically TFA-based, which also removes the trityl protecting group from the asparagine side chain. For those requiring large quantities or specific modifications, contacting a dedicated Fmoc-Asn(Trt)-Wang resin supplier for bulk orders and custom specifications is highly recommended.