In the intricate world of organic chemistry and synthesis, amino acid building blocks are fundamental components that enable the construction of complex molecules. L-Fmoc-Aspartic Acid Alpha-tert-butyl Ester, commonly known as Fmoc-Asp-OtBu (CAS: 129460-09-9), is a highly valued protected amino acid derivative widely used in peptide synthesis and other advanced chemical applications. Its unique structure offers chemists the control needed for precise molecular assembly.

The primary application of Fmoc-Asp-OtBu lies in solid-phase peptide synthesis (SPPS), a cornerstone technique for creating peptides used in pharmaceuticals, diagnostics, and research. The Fmoc protecting group on the alpha-amino function allows for sequential coupling of amino acids under mild conditions. Simultaneously, the tert-butyl ester on the aspartic acid side chain’s carboxyl group provides robust protection that can be selectively removed later in the synthesis, typically via acidolysis. This dual protection scheme ensures the integrity of the amino acid and the growing peptide chain, preventing unwanted side reactions and optimizing yield and purity.

For B2B customers, procuring essential building blocks like Fmoc-Asp-OtBu requires careful consideration of several factors. When you aim to buy this compound, looking for a reliable manufacturer who can supply it with high purity (e.g., 97%) is paramount. Chinese chemical suppliers are often the go-to source due to their extensive manufacturing capabilities and competitive pricing. It is crucial to partner with a supplier that not only offers a good price but also guarantees consistent quality and reliable delivery.

Beyond peptide synthesis, Fmoc-Asp-OtBu can also find applications in the synthesis of peptidomimetics, modified amino acids, and other complex organic molecules where controlled introduction of an aspartic acid residue is required. Its versatility makes it a valuable asset in both academic research and industrial production settings.

To ensure you secure the best value when you need to purchase Fmoc-Asp-OtBu, engage with established chemical companies that prioritize quality control and customer satisfaction. Requesting samples for evaluation and comparing the offerings from different vendors will help you identify the most suitable partner for your ongoing chemical synthesis needs. Choosing a dependable source for your amino acid building blocks is a critical step towards achieving successful synthetic outcomes.