The synthesis of complex peptides for pharmaceutical and research applications necessitates a diverse array of specialized amino acid building blocks. Fmoc-D-2-Trifluoromethylphenylalanine, identified by CAS number 352523-15-0, is one such highly valuable compound. As a non-natural amino acid derivative, it offers unique chemical properties that are instrumental in designing peptides with tailored functionalities and improved biological performance. For scientists and procurement specialists, understanding its role and how to effectively buy it is crucial.

Fmoc-D-2-Trifluoromethylphenylalanine combines the Fmoc (9-fluorenylmethoxycarbonyl) protecting group with a D-phenylalanine backbone that is further modified with a trifluoromethyl (CF3) group at the ortho position of the phenyl ring. The Fmoc group facilitates controlled solid-phase peptide synthesis (SPPS) by allowing selective deprotection under mild basic conditions. The trifluoromethyl substitution, meanwhile, imparts significant electronic and steric effects. This can lead to enhanced peptide stability against enzymatic degradation, increased lipophilicity, and altered binding interactions with biological targets. These characteristics make it an attractive choice for medicinal chemists and researchers looking to create novel peptide therapeutics or probes.

When considering the procurement of Fmoc-D-2-Trifluoromethylphenylalanine, it is imperative to focus on quality and reliability. A high purity level, typically 97% or above, is essential to ensure successful synthesis outcomes and prevent the introduction of unwanted impurities into the final peptide sequence. For those looking to purchase this specialized intermediate, partnering with reputable manufacturers and suppliers is key. Companies based in China have become significant players in the global fine chemical market, offering a wide range of Fmoc-amino acids with consistent quality and competitive pricing.

The D-chirality of this amino acid is also noteworthy. Incorporating D-amino acids into peptide sequences can confer increased resistance to proteolysis, thereby extending the in vivo half-life of therapeutic peptides. This property is highly sought after in drug development, as it can lead to improved patient compliance through less frequent dosing. Consequently, Fmoc-D-2-Trifluoromethylphenylalanine serves as a valuable tool for creating peptides with enhanced pharmacokinetic profiles and therapeutic potential.

For effective sourcing, it is recommended to engage with suppliers who provide comprehensive technical documentation, such as Certificates of Analysis (CoA), which verify the product's identity and purity. Furthermore, comparing prices and delivery times from different providers can help secure the best value. Whether for early-stage research or larger-scale production, securing a consistent supply of high-quality Fmoc-D-2-Trifluoromethylphenylalanine is vital for the success of peptide-centric projects.

In summary, Fmoc-D-2-Trifluoromethylphenylalanine (CAS: 352523-15-0) is a critical building block in modern peptide synthesis, offering unique advantages for drug discovery and research. We encourage professionals in the pharmaceutical and biotechnology sectors to buy this essential intermediate from trusted manufacturers to ensure the quality and efficacy of their peptide-based innovations. Request a quote today to explore our offerings.