The pharmaceutical industry's relentless pursuit of novel therapeutics often hinges on the availability of specialized chemical building blocks. Fmoc-D-3-(3-Thienyl)-Alanine, identified by its CAS number 220497-90-5, stands out as a critical component in the synthesis of advanced peptides with therapeutic potential. As a D-amino acid derivative featuring an Fmoc protecting group and a thiophene side chain, it offers unique advantages for drug development programs.

The Fmoc group provides a stable yet easily removable protecting shield for the alpha-amino group of the amino acid. This is fundamental in Solid Phase Peptide Synthesis (SPPS), allowing for sequential addition of amino acids to build complex peptide chains. The D-configuration of the amino acid introduces stereochemical diversity, which can be crucial for enhancing peptide stability against enzymatic degradation and modulating receptor binding interactions. The thiophene ring in the side chain adds an element of electronic richness and can influence the pharmacokinetic and pharmacodynamic properties of the resulting peptide. This makes Fmoc-D-3-(3-Thienyl)-Alanine a valuable tool for medicinal chemists designing peptides with improved half-life, efficacy, and targeting specificity.

When procuring Fmoc-D-3-(3-Thienyl)-Alanine for pharmaceutical research, emphasis must be placed on sourcing from reliable manufacturers and suppliers. The purity of the compound directly impacts the success of drug synthesis; a high purity level, typically above 97%, is essential to minimize side reactions and ensure the integrity of the final active pharmaceutical ingredient (API). This is particularly important for drug discovery pipelines where yield and purity are paramount for cost-effectiveness and regulatory compliance. Researchers looking to buy this material should prioritize suppliers who provide certificates of analysis (COA) and demonstrate robust quality control measures.

Furthermore, considering suppliers based in regions like China can often provide access to competitive pricing for bulk quantities, supporting the progression from early-stage research to potential scale-up. A partnership with a competent manufacturer ensures not only the quality of the Fmoc-D-3-(3-Thienyl)-Alanine but also the reliability of supply, a critical factor in the fast-paced environment of drug discovery. By leveraging this specialized amino acid, pharmaceutical companies can accelerate the development of innovative peptide-based drugs.