In the realm of chemical synthesis, particularly for applications in pharmaceuticals and advanced materials, the availability of versatile and high-quality building blocks is crucial. Fmoc-D-3-Trifluoromethylphenylalanine (CAS 205526-28-9) stands out as a valuable compound due to its unique structural features and the versatility imparted by both the Fmoc protecting group and the trifluoromethyl moiety. This article highlights its significance and the importance of sourcing it from a trusted Fmoc-D-3-Trifluoromethylphenylalanine supplier.

Understanding the Chemical Structure and Properties

Fmoc-D-3-Trifluoromethylphenylalanine is an unnatural amino acid derivative with the molecular formula C25H20F3NO4 and a molecular weight of approximately 455.43 g/mol. The defining features are:

  • Fmoc Protecting Group: This labile protecting group on the alpha-amino group allows for efficient and selective incorporation into peptide chains using standard Fmoc/tBu solid-phase peptide synthesis (SPPS) protocols. Its removal under mild basic conditions (e.g., piperidine) is crucial for sequential chain elongation.
  • D-Stereochemistry: As a D-amino acid, it offers the ability to introduce specific stereochemical configurations into peptides, which can significantly influence their biological activity and resistance to proteases compared to L-amino acid counterparts.
  • Trifluoromethyl Group (-CF3): Positioned at the meta-position of the phenyl ring, this electron-withdrawing group is a powerful modulator of physicochemical properties. It increases lipophilicity, which can improve membrane permeability, and enhances metabolic stability due to the strength of the C-F bond.

The compound typically appears as a white to off-white solid or powder, with reported purities often exceeding 97% or 99% by HPLC. This high purity is essential for reliable chemical synthesis.

Applications Across Disciplines

The unique combination of properties makes Fmoc-D-3-Trifluoromethylphenylalanine a versatile building block for various advanced synthesis applications:

  • Peptide Synthesis: Its primary use is in the construction of peptides with tailored properties for therapeutic, diagnostic, or research purposes.
  • Medicinal Chemistry: As a key intermediate for synthesizing peptidomimetics and small molecule drugs that incorporate modified amino acid scaffolds.
  • Materials Science: Potential applications in creating novel polymers or functionalized materials where specific chemical and physical properties are required.
  • Chemical Biology: For studying the impact of fluorinated amino acids on protein folding, stability, and function.

When planning your synthesis, sourcing high-quality materials is paramount. It is advisable to buy Fmoc-D-3-Trifluoromethylphenylalanine from a reputable Fmoc-D-3-Trifluoromethylphenylalanine supplier who can guarantee product integrity and consistent availability.

Why Choose a Chinese Manufacturer?

Many leading chemical companies globally source intermediates and specialty chemicals from China. Partnering with a reliable Fmoc-D-3-Trifluoromethylphenylalanine manufacturer in China like NINGBO INNO PHARMCHEM CO.,LTD. can provide significant advantages. These include access to advanced synthesis capabilities, cost-effectiveness due to economies of scale, and a commitment to international quality standards. We ensure that our product meets the stringent demands of modern chemical research and production.

Conclusion

Fmoc-D-3-Trifluoromethylphenylalanine is an indispensable tool for chemists and researchers engaged in complex synthesis projects. Its strategic incorporation can lead to compounds with enhanced stability, bioavailability, and specific biological activities. By selecting a trusted Fmoc-D-3-Trifluoromethylphenylalanine supplier, you ensure the quality and success of your synthetic endeavors. Contact NINGBO INNO PHARMCHEM CO.,LTD. to inquire about pricing and to secure a consistent supply of this vital chemical intermediate.