In the intricate world of fine chemicals and pharmaceutical intermediates, certain compounds stand out for their critical role in advanced synthesis. Fmoc-D-Glu-OtBu (CAS 109745-15-5) is one such essential molecule, a protected derivative of D-glutamic acid that is fundamental to many modern research and industrial applications, particularly in peptide synthesis.

Fmoc-D-Glu-OtBu, scientifically known as N-(9-Fluorenylmethyloxycarbonyl)-D-glutamic acid alpha-tert-butyl ester, boasts a molecular formula of C24H27NO6 and a molecular weight of approximately 425.47 g/mol. Its physical form is typically a white to off-white solid, and it possesses specific optical activity attributed to its chiral nature. The presence of the Fmoc group provides base-labile protection for the alpha-amino group, while the tert-butyl ester protects the side-chain carboxyl group. This dual protection strategy is crucial for its utility in controlled synthetic pathways.

The primary application of Fmoc-D-Glu-OtBu is in peptide synthesis, specifically within the framework of Fmoc solid-phase peptide synthesis (SPPS). Researchers and manufacturers utilize this compound to introduce D-glutamic acid into peptide sequences. This is particularly valuable for creating peptides with enhanced resistance to enzymatic degradation, which is a common challenge for therapeutic peptides. By using D-amino acids, the resulting peptides can achieve longer half-lives in vivo, leading to improved efficacy. Those looking to buy Fmoc-D-Glu-OtBu often do so for these specific benefits in peptide drug development.

Beyond its direct use in peptide chains, Fmoc-D-Glu-OtBu also serves as a valuable chiral building block in the synthesis of various complex organic molecules and pharmaceutical intermediates. Its well-defined stereochemistry and versatile functional groups make it an attractive starting material for creating a diverse range of bioactive compounds used in medicinal chemistry and material science.

For businesses and research institutions requiring this specialized chemical, identifying a reliable Fmoc-D-Glu-OtBu manufacturer is key. Many leading suppliers are based in China, offering a combination of advanced manufacturing capabilities, competitive pricing, and a commitment to quality. When sourcing from a China manufacturer, expect detailed specifications and adherence to international quality standards. A trusted CAS 109745-15-5 supplier will not only offer fair Fmoc-D-Glu-OtBu price points but also ensure timely delivery and provide comprehensive documentation, such as Certificates of Analysis (CoA), to confirm product integrity.

In conclusion, Fmoc-D-Glu-OtBu is a sophisticated chemical building block with significant applications. For procurement managers and scientists, partnering with a dependable peptide synthesis reagent wholesale distributor or a direct manufacturer from China offers a strategic advantage in accessing this vital compound for innovation and production.