The pharmaceutical industry relies heavily on precise chemical synthesis for the development of novel therapeutics. Within this domain, Fmoc-D-His(Trt)-OH, also known by its CAS number 135610-90-1, plays a pivotal role as a protected amino acid derivative. This compound is essential for building complex peptide-based drugs and is a key intermediate for many active pharmaceutical ingredients (APIs).

Understanding the Chemical Profile of Fmoc-D-His(Trt)-OH

Fmoc-D-His(Trt)-OH is characterized by its D-histidine core, protected with the Fmoc group on the alpha-amino group and the trityl (Trt) group on the imidazole ring. This specific protection scheme is critical for its utility in solid-phase peptide synthesis (SPPS) and other coupling reactions. The Fmoc group is base-labile, allowing for easy removal under mild conditions using reagents like piperidine, while the trityl group offers robust protection for the imidazole nitrogen, preventing unwanted reactions during peptide chain elongation. The molecular formula is C40H33N3O4, with a molecular weight of approximately 619.71 g/mol.

Synthesis and Manufacturing Excellence from China

The synthesis of Fmoc-D-His(Trt)-OH typically involves protecting the D-histidine and then sequentially attaching the Fmoc and trityl protecting groups. Manufacturers, particularly those based in China, have perfected these synthesis routes to achieve high yields and exceptional purity, often exceeding 99% as verified by HPLC. When you purchase Fmoc-D-His(Trt)-OH, ensuring that the manufacturer adheres to strict quality control protocols is paramount. These protocols typically include thorough characterization using techniques like NMR and Mass Spectrometry, alongside purity assessments.

Applications in Pharmaceutical Intermediates and Beyond

The primary application for Fmoc-D-His(Trt)-OH is in peptide synthesis, serving as a fundamental building block for peptides with therapeutic potential. These peptides can be designed to target specific diseases, offering a more precise and often safer therapeutic approach compared to traditional small molecule drugs. Its D-configuration is also important for creating peptides with enhanced stability and altered biological activity.

Furthermore, research has indicated its potential utility as a chelating agent for metal ions and in various bioconjugation strategies. For pharmaceutical companies and research institutions seeking this critical intermediate, identifying a reliable supplier of Fmoc-D-His(Trt)-OH from China is a strategic procurement decision. They offer not only competitive prices but also the capacity for large-scale production to meet the demands of clinical trials and commercial manufacturing.

When sourcing this vital pharmaceutical intermediate, engage with manufacturers that provide comprehensive technical documentation and responsive customer service to ensure your project's success.