In the intricate world of peptide synthesis, the selection of high-quality building blocks is paramount to achieving successful and reproducible results. Among these crucial components, Fmoc-Glu-OFm, identified by its CAS number 200616-18-8, stands out as a particularly valuable amino acid derivative. Its unique structure and protective group strategy make it indispensable for researchers and manufacturers engaged in creating complex peptides for a myriad of applications, from pharmaceuticals to advanced materials.

Fmoc-Glu-OFm, chemically known as Fmoc-L-glutamic acid 5-(9-fluorenylmethyl) ester, is a derivative of glutamic acid protected at its alpha-amino group with the Fmoc (9-fluorenylmethyloxycarbonyl) group and esterified at the beta-carboxyl group with a fluorenylmethyl ester. This specific protection strategy is designed to facilitate Solid Phase Peptide Synthesis (SPPS), a cornerstone technique in modern peptide chemistry. The Fmoc group allows for facile deprotection under mild basic conditions, compatible with the acid-labile resin and side-chain protecting groups commonly used in SPPS. The esterification of the side-chain carboxyl group with a fluorenylmethyl moiety offers an additional layer of orthogonal protection, ensuring selective reactions and minimizing side product formation.

The primary application of Fmoc-Glu-OFm lies in its role as a monomer in the construction of peptide chains. By coupling this protected amino acid to a growing peptide chain on a solid support, chemists can systematically build peptides with precise sequences. Its utility is particularly pronounced when introducing glutamic acid residues with specific modifications or when the side-chain carboxyl group needs to be masked during subsequent synthetic steps. Researchers often seek to buy Fmoc-Glu-OFm from reputable manufacturers to guarantee the high purity and stereochemical integrity required for biologically active peptides. A high purity level, typically exceeding 98% as determined by HPLC, is essential to prevent the incorporation of truncated or modified sequences, which could compromise the efficacy and safety of the final peptide product.

Sourcing Fmoc-Glu-OFm from a reliable supplier, especially from a leading manufacturer in China, offers several advantages. These include competitive pricing, consistent quality control, and a robust supply chain, which are critical for both small-scale research and large-scale manufacturing. Understanding the product specifications, such as its molecular formula (C34H29NO6) and molecular weight (547.60), is also vital for accurate reaction calculations. Furthermore, reliable suppliers often provide detailed product documentation, including Certificates of Analysis (CoA) and Safety Data Sheets (SDS), ensuring compliance and safe handling practices. When looking to purchase Fmoc-Glu-OFm, consider partners who demonstrate a strong commitment to quality and customer support, facilitating your progress in peptide discovery and development.

In summary, Fmoc-Glu-OFm is more than just an intermediate; it is a precision tool that empowers scientists to construct complex peptides with unparalleled accuracy. Its unique protective group combination and high purity make it a preferred choice for advanced peptide synthesis. By partnering with a dependable manufacturer and supplier, researchers can ensure the consistent availability of this critical building block, thereby accelerating their journey from laboratory research to potential therapeutic innovations.