For many in the peptide synthesis community, understanding the factors that influence the Fmoc-His(Boc)-OH price is crucial for budgeting and strategic procurement. As a vital reagent for incorporating histidine into peptide chains, its cost can impact overall project expenses, especially for large-scale manufacturing or extensive research projects. The market price of Fmoc-His(Boc)-OH is influenced by several key variables, including raw material costs, manufacturing complexity, purity levels, and supplier location.

As a specialized amino acid derivative, the synthesis of Fmoc-His(Boc)-OH involves multi-step chemical processes that require precise control and high-quality inputs. The purity achieved, often measured by HPLC (e.g., ≥98%), is a significant determinant of cost. Higher purity grades command higher prices due to the rigorous purification steps and analytical testing involved. Furthermore, the scale of production plays a role; when you buy Fmoc-His(Boc)-OH in bulk, the per-gram price typically decreases substantially due to economies of scale.

For researchers and companies looking to procure this essential reagent, seeking out a reliable Fmoc-His(Boc)-OH supplier is paramount. Suppliers based in regions like China often offer competitive pricing due to manufacturing efficiencies and supply chain advantages. When comparing prices, it's important to look beyond the sticker price and consider the total value proposition, which includes product quality, consistency, lead times, and customer support. Many suppliers offer tiered pricing structures for different quantities, making Fmoc-His(Boc)-OH bulk purchase an attractive option for larger operations.

The strategic use of Fmoc-His(Boc)-OH is critical for minimizing epimerization in Solid Phase Peptide Synthesis (SPPS), thereby ensuring the purity and biological activity of the final peptide. Investing in a high-quality product from a trusted Fmoc-His(Boc)-OH manufacturer, even if it means a slightly higher initial cost, can prevent costly downstream issues and rework. Therefore, balancing cost with quality and reliability is key when making purchasing decisions for your peptide synthesis needs.