In the intricate world of peptide synthesis and related biochemical applications, specific amino acid derivatives are indispensable tools. Fmoc-Lys-OH HCl, also known as Nalpha-Fmoc-L-lysine Hydrochloride (CAS: 139262-23-0), is one such compound that plays a pivotal role. Its unique structure, featuring the Fmoc protecting group and a reactive lysine side chain, makes it a highly versatile building block for researchers and manufacturers alike. This article highlights the significant applications of Fmoc-Lys-OH HCl and provides guidance for those looking to buy this critical reagent.

The Foundation of Peptide Synthesis

Fmoc-Lys-OH HCl is a cornerstone in modern solid-phase peptide synthesis (SPPS). The Fmoc group offers a stable yet easily removable protection strategy for the alpha-amino group of lysine, an essential amino acid with a functionalizable side chain. This allows for precise control during the step-wise addition of amino acids to a growing peptide chain. The lysine side chain’s primary amine is available for further chemical modifications, such as labeling, conjugation, or introduction of specific functional groups, which is vital for creating complex peptides with tailored properties for therapeutic or diagnostic purposes.

Applications in Drug Conjugation and Targeted Therapies

The lysine side chain’s amine group makes Fmoc-Lys-OH HCl an ideal linker component in the development of antibody-drug conjugates (ADCs) and other targeted drug delivery systems. By strategically incorporating this derivative into a peptide linker or directly conjugating it to a drug molecule and an antibody, researchers can create sophisticated systems that deliver therapeutic agents directly to target cells. The ability to reliably source high-purity Fmoc-Lys-OH HCl from manufacturers is crucial for the development and production of these advanced therapies.

Biochemical Research and Fluorescent Labeling

Beyond peptide synthesis, Fmoc-Lys-OH HCl is also employed in the creation of biochemical tools for research. It is a precursor in the synthesis of fluorescently tagged lysine derivatives that are used to detect protease cleavage events. These probes are invaluable for studying enzyme kinetics, cellular signaling pathways, and disease progression. For scientists engaged in this area, ensuring a consistent supply of quality Fmoc-Lys-OH HCl from a reputable supplier is essential for reproducible and accurate results.

Sourcing Strategies for B2B Customers

When you need to buy Fmoc-Lys-OH HCl, partnering with a reliable manufacturer is key. Factors to consider include product purity (typically ≥98% HPLC), batch-to-batch consistency, available packaging options (from grams to bulk quantities), and competitive pricing. As a dedicated supplier, we are committed to providing high-quality Fmoc-Lys-OH HCl that meets the stringent requirements of peptide synthesis and related applications. We encourage you to contact us for a quote and to discuss your specific needs, ensuring you have a dependable source for this vital compound.