Fmoc-N-methyl-D-alanine, identified by CAS number 138774-92-2, is a sophisticated organic molecule that serves as a key component in various chemical synthesis pathways, particularly within the realms of peptide chemistry and pharmaceutical development. For scientists and procurement specialists seeking high-performance intermediates, understanding the molecular structure and its resultant applications is fundamental. As a premier manufacturer and supplier, we aim to provide clarity on this valuable compound.

Molecular Structure and Properties

The chemical formula of Fmoc-N-methyl-D-alanine is C19H19NO4, with a molecular weight of 325.36 g/mol. Its structure features an alanine backbone that has been methylated at the nitrogen atom and protected with the Fmoc group. The Fmoc moiety is a bulky, base-labile protecting group that shields the amine functionality, allowing for selective coupling reactions. The presence of the N-methyl group on the alanine residue introduces a chiral center and can impact the conformation and solubility of peptides derived from it. Typically supplied as a white powder, it requires storage at 2-8°C to maintain its stability.

Applications in Chemical Synthesis

The primary application of Fmoc-N-methyl-D-alanine lies in its use as a specialized building block in peptide synthesis. It is particularly valuable for constructing peptides that require N-methylated amino acids, which can confer unique properties such as increased protease resistance or altered receptor binding. This makes it a sought-after intermediate for researchers developing peptide-based therapeutics, diagnostic agents, and biomaterials. Beyond peptide synthesis, it can also serve as a chiral auxiliary or a starting material for the synthesis of other complex organic molecules.

Procurement from Leading Suppliers

When you need to buy Fmoc-N-methyl-D-alanine, partnering with a reputable supplier is crucial. Many companies specialize in high-purity organic intermediates and offer this compound with a purity of 98% or higher. Identifying a trusted manufacturer in regions like China can provide access to competitive pricing and consistent supply. Always request a Certificate of Analysis (COA) to confirm product specifications and ensure compliance with your project’s requirements. Understanding the product’s physical characteristics, such as its typical white powder appearance, is also part of the quality assessment process.

The Importance for Research and Development

The strategic use of advanced intermediates like Fmoc-N-methyl-D-alanine is integral to driving innovation in chemical research and development. Its availability from reliable sources ensures that scientists can explore novel molecular designs and synthesis pathways without compromise. Whether your work involves custom peptide synthesis, drug discovery, or other complex organic transformations, this derivative offers a powerful tool to achieve precise molecular construction. As a dedicated manufacturer, we are committed to providing the high-quality materials that fuel scientific advancement.