The advancement of modern medicine and biotechnology is heavily reliant on the precise synthesis of peptides – molecules that play critical roles in biological processes. For scientists and manufacturers in this field, understanding and procuring the right chemical intermediates is paramount. One such indispensable intermediate is Fmoc-Phenylalanine (Fmoc-Phe-OH), identified by its CAS number 286460-71-7. This protected amino acid derivative is a cornerstone in the widely adopted Fmoc solid-phase peptide synthesis (SPPS) methodology.

The utility of Fmoc-Phe-OH stems from its structure: a phenylalanine amino acid moiety protected at the N-terminus by the base-labile Fmoc group. This protection strategy allows for sequential coupling of amino acids. The Fmoc group can be selectively removed under mild basic conditions, exposing a reactive amine that can then readily couple with the next Fmoc-protected amino acid. This controlled stepwise addition is crucial for building long, complex peptide sequences with high fidelity. Phenylalanine itself is a vital amino acid, contributing unique hydrophobic and aromatic properties to peptides, often influencing their tertiary structure and interactions with biological targets.

When researchers and procurement managers decide to buy Fmoc-Phe-OH, they are seeking a reliable source of high-purity material. The appearance of Fmoc-Phe-OH is typically a white powder, and its stability necessitates proper storage, often at refrigerated temperatures (2-8°C). The quality of this intermediate directly impacts the efficiency of peptide coupling reactions and the overall purity of the final synthesized peptide. Impurities in the Fmoc-Phe-OH can lead to truncated sequences, side reactions, and ultimately, a less effective or even inactive peptide product.

Therefore, selecting a reputable manufacturer and supplier is key. Many organizations look to established chemical suppliers, including those in China known for their manufacturing capabilities, to secure Fmoc-Phe-OH at competitive prices. A thorough evaluation of potential suppliers should include reviewing their quality control measures, consistency of product, and ability to provide timely delivery and comprehensive documentation, such as Certificates of Analysis. By ensuring the quality of this critical intermediate, researchers and manufacturers can confidently advance their peptide synthesis projects, leading to innovations in therapeutics, diagnostics, and fundamental biological research.