The journey from laboratory discovery to a viable therapeutic or diagnostic tool is long and complex, often requiring highly specialized reagents to unravel intricate biological mechanisms. Folic Acid labeled with Carbon-13 (13C5) and Nitrogen-15 (15N), identified by CAS number 2687960-47-8, is a prime example of such a reagent, offering unparalleled precision for a range of advanced applications in drug discovery and diagnostics.

As a vital B vitamin, folic acid is intrinsically linked to fundamental cellular processes, making it a key target and pathway in various biomedical research areas. Its labeled form allows researchers to gain a level of insight that would otherwise be unattainable.

Here are some of the key applications where Folic Acid-13C5, 15N plays a crucial role:

1. Targeted Drug Delivery Systems: Many cancer cells exhibit upregulated folate receptors for their rapid proliferation. This presents an opportunity for targeted drug delivery, where drugs can be conjugated to folic acid to specifically target cancer cells while sparing healthy tissues. Labeled folic acid can be used in preclinical studies to track the uptake and distribution of these targeted delivery systems, optimizing their design and efficacy. Researchers developing such novel therapies often need to buy these labeled compounds to validate their targeting mechanisms.

2. Pharmaceutical ADME/PK Studies: Understanding how a drug is absorbed, distributed, metabolized, and excreted (ADME) is critical for its development. When a drug candidate interacts with folate pathways or mimics folate, labeled folic acid serves as an indispensable tool. It can be used as an internal standard in LC-MS/MS assays to accurately quantify the drug's concentration in biological fluids, or to study its competition with endogenous folate for transporters and metabolic enzymes. This precision is vital for pharmaceutical manufacturers aiming to buy reliable research materials.

3. Diagnostic Biomarker Development: Altered folate metabolism is implicated in various diseases, including certain cancers and neurological disorders. Labeled folic acid can aid in the development and validation of diagnostic assays designed to detect specific metabolic profiles or biomarkers associated with these conditions. By providing a precise standard, it helps ensure the accuracy and reliability of new diagnostic tests.

4. Mechanistic Studies in Disease Research: Investigating the precise role of folate metabolism in diseases like Alzheimer's, cardiovascular disease, or specific types of cancer often requires tracing metabolic flux. Labeled folic acid allows researchers to map metabolic pathways, identify rate-limiting steps, and understand how disease states disrupt normal folate processing. This foundational research is critical for identifying new therapeutic targets.

5. Nutraceutical and Supplement Research: The efficacy and bioavailability of dietary supplements containing folic acid or its derivatives are of significant interest. Labeled folic acid can be used to study how different formulations or co-ingested substances affect folic acid absorption and utilization in the body. This supports the development of more effective nutritional interventions.

As a leading manufacturer and supplier of high-purity Folic Acid-13C5, 15N, we are committed to providing the scientific community with the tools they need to push the boundaries of biomedical research. Our product's defined isotopic enrichment and chemical purity make it a reliable choice for critical applications in drug discovery, diagnostics, and fundamental research. We are dedicated to being a trusted source for these advanced reagents, offering both quality and value to researchers worldwide.