For research and development chemists, understanding the precise properties and formulation potential of key chemical compounds is fundamental to innovation. R-Alpha-Lipoic Acid, chemically known as (R)-(+)-1,2-Dithiolane-3-pentanoic acid and identified by CAS 1200-22-2, is a compound of significant interest due to its potent biological activity and versatility. This article aims to provide chemists and formulators with critical insights into RALA, including its chemical characteristics, application potential, and how to source it effectively from manufacturers.

Chemical Profile and Properties of R-Alpha-Lipoic Acid

R-Alpha-Lipoic Acid is a cyclic fatty acid containing two sulfur atoms in a disulfide bond. Its molecular formula is C8H14O2S2, with a molecular weight of 206.33 g/mol. The distinguishing feature of RALA is its stereochemistry; the 'R' configuration (CAS 1200-22-2) is the naturally occurring enantiomer and is significantly more biologically active than its 'S' counterpart. Its pKa of approximately 4.7 suggests it acts as a weak acid. In its pure form, it appears as a yellow crystalline powder.

Key properties that make RALA attractive for formulation include:

  • Antioxidant Efficacy: Its ability to scavenge free radicals, protect cellular membranes, and regenerate other antioxidants like Vitamin C and E.
  • Mitochondrial Support: Involvement in the Krebs cycle and electron transport chain, contributing to cellular energy production (ATP synthesis).
  • Metal Chelation: The capacity to bind to certain metal ions, which can be beneficial in specific biological contexts.
  • Stability: While lipoic acid can be sensitive to light and heat, the R-form exhibits good stability in various formulations when properly stored and handled.

Applications in Research and Product Development

The unique chemical and biological profile of R-Alpha-Lipoic Acid makes it a valuable ingredient across several sectors:

  • Pharmaceuticals: As an active pharmaceutical ingredient (API) or key component in drugs targeting oxidative stress-related diseases, metabolic disorders, and neurodegenerative conditions.
  • Nutraceuticals: Widely used in dietary supplements for antioxidant, anti-aging, and metabolic support benefits.
  • Cosmetics: Incorporated into advanced skincare formulations for its anti-aging and skin-conditioning properties.

When considering buy R-Alpha-Lipoic Acid for your research or product development, it is crucial to obtain it from a reliable chemical supplier who can provide lot-specific Certificates of Analysis (CoA) confirming its identity, purity, and stereochemical integrity.

Sourcing R-Alpha-Lipoic Acid: Finding the Right Manufacturer

For chemists and procurement specialists, identifying a dependable source for CAS 1200-22-2 is paramount. Many research institutions and chemical companies source their high-purity R-Alpha-Lipoic Acid from specialized manufacturers, often located in China, who can guarantee consistent quality and competitive pricing. When inquiring about price and availability, always look for suppliers who clearly state the product is the R-form (CAS 1200-22-2) and provide detailed technical data.

We understand the critical needs of researchers and product developers. As a dedicated manufacturer and supplier, we offer high-quality R-Alpha-Lipoic Acid (CAS 1200-22-2) suitable for demanding applications. Contact us today to request a quote and discuss your specific formulation requirements.