For businesses involved in pharmaceutical research, development, and manufacturing, sourcing critical intermediates like 4-(4-Bromo-3-formylphenoxy)benzonitrile (CAS: 906673-54-9) is a strategic imperative. This article aims to provide procurement professionals with insights into the global supply landscape, focusing on pricing, key manufacturers, and effective sourcing strategies to buy this vital chemical.

The Market for 4-(4-Bromo-3-formylphenoxy)benzonitrile:

As a key intermediate for high-value pharmaceuticals, such as Crisaborole, the demand for 4-(4-Bromo-3-formylphenoxy)benzonitrile remains consistent. The market is characterized by a network of specialized chemical manufacturers, primarily located in regions with robust chemical synthesis capabilities. China, in particular, has emerged as a significant hub for the production of such intermediates, offering competitive pricing and substantial manufacturing capacity.

Factors Influencing Price:

The price of 4-(4-Bromo-3-formylphenoxy)benzonitrile can fluctuate based on several factors:

  • Purity and Grade: Pharmaceutical-grade material with high purity (typically >99%) will command a higher price than technical-grade compounds. The specific analytical methods and certification requirements also play a role.
  • Order Volume: As with most chemical intermediates, bulk purchases generally lead to a lower price per kilogram. Manufacturers are often willing to offer significant discounts for larger quantities.
  • Raw Material Costs: Fluctuations in the prices of precursor chemicals, such as 4-fluorobenzonitrile and 2-bromo-5-hydroxybenzaldehyde, can impact the final product cost.
  • Manufacturing Complexity: The multi-step synthesis process for this compound requires specialized equipment and expertise, contributing to its overall price.
  • Supplier Type: Direct manufacturers typically offer more competitive pricing than distributors or trading companies, especially for large orders.

Identifying Key Manufacturers and Suppliers:

When looking to buy 4-(4-Bromo-3-formylphenoxy)benzonitrile, a strategic search for reputable manufacturers is essential. Leading suppliers are often found in:

  • China: Companies like Shandong Boyuan Pharmaceutical Co., Ltd., Nanjing CHICO Pharmaceutical Co., Ltd., and Henan Lihao Chem Plant Limited are frequently listed as manufacturers and suppliers. These companies often have extensive experience in producing pharmaceutical intermediates and can offer competitive prices and large-scale production capabilities.
  • Other Regions: While China dominates, manufacturers in the United States and India also exist, though they may cater to different market segments or offer specialized services.

When evaluating potential suppliers, it's crucial to request detailed quotations that specify:

  • Unit price (e.g., USD/kg)
  • Minimum order quantity (MOQ)
  • Purity and analytical specifications
  • Lead time for delivery
  • Payment terms (e.g., T/T, L/C)
  • Shipping terms (e.g., EXW, FOB, CIF)

Strategic Procurement Recommendations:

  1. Request Multiple Quotes: Engage with several suppliers to compare pricing, terms, and delivery schedules.
  2. Verify Supplier Credentials: Look for suppliers with established reputations, certifications, and positive customer feedback.
  3. Prioritize Quality Assurance: Ensure that the supplier can provide a Certificate of Analysis (CoA) for each batch.
  4. Negotiate for Long-Term Contracts: For significant, ongoing needs, negotiate supply agreements that ensure price stability and guaranteed availability.

By understanding the market dynamics and employing a systematic approach to sourcing, businesses can effectively procure high-quality 4-(4-Bromo-3-formylphenoxy)benzonitrile, ensuring the smooth operation of their pharmaceutical and chemical synthesis processes.