In the relentless pursuit of novel therapeutics, medicinal chemists constantly seek innovative molecular scaffolds and building blocks. Boc-1-Aminocyclobutanecarboxylic Acid (CAS: 120728-10-1) has gained significant traction in drug discovery programs due to its unique structural features and versatility as a pharmaceutical intermediate. This article delves into why this compound is becoming increasingly important and how researchers and procurement professionals can effectively source it.

Structural Advantages and Applications

The defining characteristic of Boc-1-Aminocyclobutanecarboxylic Acid is its rigid cyclobutane ring, coupled with a Boc-protected amino group and a carboxylic acid functionality. This combination offers several advantages for drug design:

  • Conformational Rigidity: The cyclobutane ring restricts conformational flexibility, which can be crucial for optimizing binding interactions with biological targets, leading to enhanced potency and selectivity of drug candidates.
  • Metabolic Stability: The cyclobutane structure can offer increased resistance to metabolic breakdown compared to more flexible acyclic analogues, potentially improving a drug's pharmacokinetic profile.
  • Scaffold for Diversity: The functional groups present allow for diverse chemical modifications, enabling medicinal chemists to explore structure-activity relationships (SAR) and fine-tune the properties of potential drugs.

These properties make Boc-1-Aminocyclobutanecarboxylic Acid a valuable intermediate in the synthesis of a wide range of therapeutic agents, including those targeting neurological disorders, infectious diseases, and oncology.

Sourcing Strategy for Drug Discovery Programs

For research teams and procurement managers involved in drug discovery, securing a reliable and high-quality supply of Boc-1-Aminocyclobutanecarboxylic Acid is essential. When considering procurement, key factors include:

  • Purity and Documentation: Pharmaceutical development demands stringent purity standards. Suppliers must provide detailed Certificates of Analysis (CoA) confirming purity levels and identifying potential impurities.
  • Supplier Expertise: Partnering with manufacturers experienced in producing pharmaceutical intermediates ensures adherence to quality control measures and consistent product availability.
  • Competitive Pricing: Obtaining quotes from various suppliers, especially those in regions with established chemical manufacturing capabilities like China, is a prudent strategy to manage research budgets. The price of Boc-1-Aminocyclobutanecarboxylic Acid can be optimized through bulk purchasing.
  • Lead Times: In the fast-paced environment of drug discovery, timely delivery is critical. Understanding the supplier's lead times and stock availability is important for project planning.

Finding the Right Supplier

To effectively buy Boc-1-Aminocyclobutanecarboxylic Acid, use targeted search terms such as 'Boc-1-Aminocyclobutanecarboxylic acid for drug discovery,' 'pharmaceutical intermediate supplier,' 'CAS 120728-10-1 manufacturer,' and 'buy chemical building blocks.' Engaging with B2B chemical platforms can help identify leading manufacturers and suppliers who can meet the rigorous demands of pharmaceutical R&D.

In conclusion, Boc-1-Aminocyclobutanecarboxylic Acid represents a significant asset in the drug discovery toolkit. Its unique structural attributes and versatility as a pharmaceutical intermediate make it a compound of growing importance. By focusing on reliable sourcing from experienced manufacturers and suppliers, research organizations can ensure they have access to this vital building block for advancing their therapeutic pipelines.