Guanosine 5'-Triphosphate Disodium Salt (CAS 56001-37-7), or GTP disodium salt, is a critical nucleotide with specialized applications that extend beyond its fundamental roles in cellular energy and protein synthesis. Its unique properties make it an invaluable tool for sophisticated biochemical and pharmaceutical research, particularly in the development of affinity probes and as a potential therapeutic target modulator.

One of the key advanced applications of GTP disodium salt lies in the preparation of photoreactive GTP affinity probes. These probes are synthesized by chemically modifying GTP to include a photoreactive group. When exposed to UV light, these probes covalently bind to proteins that interact with GTP, allowing researchers to identify and study these protein targets. This technique is instrumental in mapping protein-ligand interactions and understanding complex cellular pathways. Researchers looking for 'GTP for affinity probe synthesis' will often search for high-purity grades from specialized suppliers.

Furthermore, GTP disodium salt has garnered attention for its role as an inhibitor of eukaryotic initiation factor eIF-4E. This protein is a critical regulator of mRNA translation and is often overexpressed in various cancers, making it a significant target for anti-cancer drug development. By inhibiting eIF-4E, GTP disodium salt or derivatives thereof can potentially suppress tumor growth. This application highlights its importance as a pharmaceutical intermediate and a subject of intense drug discovery research. Sourcing reliable GTP disodium salt from a manufacturer is crucial for these preclinical studies.

For scientists and procurement managers, securing a consistent supply of high-quality GTP disodium salt is essential for these specialized research areas. When searching for a Guanosine 5'-Triphosphate Disodium Salt manufacturer or supplier, it's important to verify their adherence to quality standards, such as assay purity (often ≥98.0%), and their capacity to provide necessary documentation like Certificates of Analysis. Manufacturers in China are increasingly recognized for their capability to produce such high-grade biochemicals at competitive prices.

In summary, GTP disodium salt is a versatile compound with critical applications in advanced research methodologies. Its use in synthesizing affinity probes and its inhibitory action on eIF-4E underscore its importance in driving innovation in biotechnology and pharmaceutical development. Ensuring a dependable source for this key biochemical empowers researchers to push the boundaries of scientific discovery.