(R)-4-Benzyl-2-oxazolidinone, identified by its CAS number 102029-44-7, is a fundamental chiral building block with significant utility in organic synthesis, particularly within the pharmaceutical sector. Understanding its properties and applications is key for any procurement specialist or research scientist looking to enhance their synthetic capabilities.

Key Chemical and Physical Properties

This compound typically presents as a white to light yellow crystalline powder. Its molecular formula is C10H11NO2, with a molecular weight of 177.20 g/mol. A critical characteristic is its optical activity, often reported as +64.0° (c=1, CHCl3), indicating its specific stereochemical configuration. It exhibits good solubility in organic solvents like chloroform, facilitating its use in various reaction conditions. The melting point generally falls within the range of 87-90°C, providing a stable solid form for handling and storage.

Versatile Applications in Pharmaceutical Development

The primary value of (R)-4-Benzyl-2-oxazolidinone lies in its role as a chiral auxiliary and intermediate in the enantioselective synthesis of complex pharmaceutical compounds. Its applications include:

  • Synthesis of Zolmitriptan and Aliskiren: It serves as a crucial intermediate in the manufacturing pathways of these important drugs.
  • Chiral Synthesis of Beta-Lactams and Amino Acids: Essential for creating stereochemically pure beta-lactams and alpha-amino acids, which are vital for many therapeutic agents.
  • HIV Protease Inhibitors: Used in the preparation of specific carbocyclic nucleosides required for these antiviral drugs.
  • Chiral Auxiliary in Asymmetric Synthesis: Guides reactions to produce desired enantiomers with high selectivity.

Procurement and Sourcing Strategies

When seeking to buy (R)-4-Benzyl-2-oxazolidinone, it is essential to partner with reliable suppliers. Many leading manufacturers in China specialize in providing high-purity pharmaceutical intermediates like CAS 102029-44-7. By comparing (R)-4-Benzyl-2-oxazolidinone price from different vendors, procurement managers can secure cost-effective solutions without compromising on quality. As a trusted pharmaceutical intermediate supplier, these companies ensure stringent quality control and consistent availability.

For companies looking to optimize their synthetic routes for chiral drugs, understanding the detailed specifications and applications of (R)-4-Benzyl-2-oxazolidinone is a significant advantage. Exploring options to purchase (R)-4-Benzyl-2-oxazolidinone from reputable sources is a strategic step towards successful drug development.

This compound remains a vital tool for chemists, enabling the creation of precisely structured molecules that are the foundation of modern pharmaceuticals.