For researchers engaged in cutting-edge organic synthesis and peptide development, precision and reliability in chemical reagents are non-negotiable. H-D-Lys-OMe·2HCl (CAS 66494-53-9) stands out as a frequently utilized chiral building block. This article serves as a practical guide for R&D scientists, detailing the key specifications and proper handling procedures for this essential amino acid derivative, and emphasizing the importance of sourcing from a reputable manufacturer.

Understanding the technical specifications of H-D-Lys-OMe·2HCl is fundamental to its effective use. The compound’s CAS number, 66494-53-9, provides a unique identifier for accurate sourcing. Its molecular formula is C12H25ClN2O4, with a molecular weight of approximately 296.79 g/mol. Typically, it is supplied as a white crystalline powder. For synthesis applications, key specifications to verify with your supplier include purity (often stated as ≥98.0%), optical rotation (confirming the D-configuration), and moisture content. These parameters directly influence the success and reproducibility of your reactions.

Proper handling and storage are critical to maintaining the integrity of H-D-Lys-OMe·2HCl. As a dihydrochloride salt, it is generally hygroscopic, meaning it can absorb moisture from the atmosphere. Therefore, it is advisable to store the compound in a tightly sealed container in a cool, dry place, typically refrigerated at -20°C. Before weighing or using, allow the container to equilibrate to room temperature in a desiccator to prevent condensation and minimize exposure to ambient moisture.

When working with H-D-Lys-OMe·2HCl in synthesis, several best practices can enhance reaction outcomes:

  1. Solvent Selection: Ensure appropriate solvents are used for dissolution. Polar protic or aprotic solvents like DMF, DMSO, or water are often suitable, depending on the reaction conditions. Always verify solubility data from reliable sources or the manufacturer.
  2. Reaction Conditions: Pay close attention to reaction temperature, pH, and reagent stoichiometry. For peptide coupling, using appropriate coupling agents and activators is essential for efficient amide bond formation.
  3. Purification: Understand that residual salts or byproducts may require specific purification techniques, such as chromatography or recrystallization, to obtain the desired final product purity.

For R&D scientists, sourcing H-D-Lys-OMe·2HCl from a trusted manufacturer is paramount. A reliable supplier will not only provide high-purity material but also offer comprehensive documentation, including Certificates of Analysis (CoA) and Safety Data Sheets (SDS). These documents are invaluable for laboratory safety and experimental planning. We understand the critical needs of research scientists and are dedicated to being your go-to supplier for quality H-D-Lys-OMe·2HCl, offering competitive pricing and responsive customer support.

By adhering to these guidelines and choosing a dependable supplier, R&D scientists can ensure the consistent performance of H-D-Lys-OMe·2HCl in their projects, paving the way for scientific advancements.