In the intricate world of pharmaceutical synthesis, the availability of high-quality intermediates is crucial for the efficient development of new drugs. H-Glu-OtBu, or L-Glutamic acid alpha-tert-butyl ester (CAS 45120-30-7), stands out as a versatile and indispensable pharmaceutical intermediate. Its unique chemical structure makes it a fundamental building block for a variety of therapeutic agents, including peptide-based drugs, Antibody-Drug Conjugates (ADCs), and Proteolysis Targeting Chimeras (PROTACs).

The Chemical Profile of H-Glu-OtBu

H-Glu-OtBu is derived from L-Glutamic acid, an amino acid. The esterification of the alpha carboxyl group with a tert-butyl group provides protection during synthetic manipulations. This protection strategy is common in peptide and organic synthesis, allowing for selective reactions at other functional groups. Key properties that make H-Glu-OtBu valuable include:

  • Chemical Formula: C9H17NO4
  • Molecular Weight: Approximately 203.24 g/mol
  • CAS Number: 45120-30-7
  • Appearance: Typically a white powder

These characteristics are vital for researchers and chemists who need to precisely control reactions and ensure the desired stereochemistry and purity of their synthesized compounds.

Applications as a Pharmaceutical Intermediate

The utility of H-Glu-OtBu extends across several critical areas in pharmaceutical R&D:

  • Peptide Synthesis: As a protected amino acid, it is fundamental for constructing peptides with specific sequences and functionalities.
  • ADC Linker Synthesis: It is a common component in creating stable linkers that connect cytotoxic payloads to antibodies.
  • PROTAC Synthesis: It serves as a building block for linkers that connect target protein ligands with E3 ligase recruiters.
  • General Organic Synthesis: Its functional groups make it adaptable for various synthetic routes in the development of small molecule drugs.

Sourcing H-Glu-OtBu: The Importance of a Reliable Manufacturer

Given its critical role, obtaining H-Glu-OtBu from a reputable manufacturer and supplier is essential. The quality and consistency of this intermediate directly influence the success of complex drug synthesis pathways. Impurities can lead to failed reactions, costly purification steps, and delays in project timelines.

NINGBO INNO PHARMCHEM CO.,LTD. specializes in providing high-purity pharmaceutical intermediates, including H-Glu-OtBu. We understand the importance of quality assurance, competitive pricing, and reliable supply for our clients in the pharmaceutical industry. Our manufacturing facilities in China adhere to strict quality control protocols, ensuring that our products meet the demanding standards of drug development.

Why Partner with Us?

  • Guaranteed Purity: Our H-Glu-OtBu is supplied with comprehensive analytical data to ensure it meets your specifications.
  • Competitive Pricing: We offer cost-effective solutions for both research quantities and bulk orders.
  • Flexible Supply Options: We cater to diverse needs, including custom synthesis and large-volume orders.
  • Expert Support: Leverage our knowledge in chemical synthesis and supply chain management.

For your next pharmaceutical synthesis project, trust NINGBO INNO PHARMCHEM CO.,LTD. as your reliable supplier of H-Glu-OtBu. Contact us today to request a quote or to learn more about how our high-quality intermediates can support your drug discovery and development efforts.