The pharmaceutical industry relies heavily on a vast array of chemical intermediates to drive innovation and bring life-saving treatments to market. Among these, boronic acids and their derivatives have emerged as exceptionally valuable building blocks, particularly in complex synthetic pathways. 3-(Hydroxymethyl)phenylboronic acid (CAS: 87199-15-3) is one such compound, playing a pivotal role in the synthesis of advanced Active Pharmaceutical Ingredients (APIs). For R&D scientists and procurement managers, understanding the utility and sourcing of this intermediate is key to successful drug development.

The Chemical Profile of 3-(Hydroxymethyl)phenylboronic Acid

With its chemical formula C7H9BO3 and molecular weight of 151.96, 3-(Hydroxymethyl)phenylboronic acid is a versatile molecule. Its structure, featuring both a hydroxymethyl group and a boronic acid moiety on a phenyl ring, allows for diverse chemical transformations. It is typically supplied as an off-white powder with a high purity, often exceeding 98.0% assay. This high purity is critical for pharmaceutical synthesis, where even trace impurities can impact the efficacy, safety, and regulatory approval of an API.

Applications in API Synthesis

The primary application of 3-(Hydroxymethyl)phenylboronic acid in the pharmaceutical sector is as an intermediate for synthesizing potent drugs. A prime example is its use in the production of Pacritinib/SB-1518, a Janus kinase (JAK) inhibitor used in the treatment of myelofibrosis. The boronic acid functional group is often utilized in cross-coupling reactions, such as the Suzuki-Miyaura coupling, which are fundamental for building complex molecular architectures found in many modern pharmaceuticals. Researchers constantly explore new synthetic routes utilizing this compound to develop novel therapeutic agents.

Procurement Considerations for Pharmaceutical Companies

Procurement managers in the pharmaceutical industry face rigorous demands when sourcing raw materials. For 3-(Hydroxymethyl)phenylboronic acid, this means partnering with chemical manufacturers and suppliers who adhere to strict quality control standards. Key considerations include:

  • Purity and Consistency: Ensuring batch-to-batch consistency and high assay values (≥98.0%) is non-negotiable.
  • Supply Chain Reliability: A stable and predictable supply chain is essential for continuous manufacturing processes.
  • Regulatory Compliance: Suppliers should be able to provide necessary documentation and meet regulatory requirements for pharmaceutical intermediates.
  • Technical Support: Access to expert technical advice for product application and troubleshooting is invaluable.

When looking to buy this intermediate, it is advisable to seek out established chemical suppliers who specialize in pharmaceutical building blocks. Inquiring about their manufacturing capabilities, quality management systems, and capacity for large-scale production will ensure a secure supply for both research and commercial needs.

In summary, 3-(Hydroxymethyl)phenylboronic acid is a highly sought-after intermediate in pharmaceutical synthesis due to its versatility and importance in creating advanced APIs. For R&D scientists, it's a tool for innovation, and for procurement professionals, it represents a critical component in a robust supply chain. Ensuring quality and reliability from your chemical manufacturer is the first step towards successful drug development.