Hypromellose (HPMC) is a cornerstone excipient in the pharmaceutical industry, valued for its versatility. However, understanding the various viscosity grades and their implications for different applications can be a challenge for buyers. NINGBO INNO PHARMCHEM CO.,LTD., a premier manufacturer and supplier of pharmaceutical-grade HPMC, provides essential insights to help you effectively choose and buy the correct viscosity grade for your needs.

The viscosity of an HPMC solution is one of its most defining characteristics and directly dictates its performance in pharmaceutical formulations. Viscosity is typically measured in centipoise (cP) or milliPascal-seconds (mPa·s) for a specified concentration of HPMC in water (commonly 2% or 1.9% dry basis) at a controlled temperature (usually 20°C or 25°C). The different viscosity grades, such as those designated by the 'E' and 'K' series, are crucial for tailoring the functional properties of the HPMC.

How Viscosity Impacts HPMC Functionality:

  • Thickening Agent: Higher viscosity grades are more effective at increasing the viscosity of liquid formulations, such as eye drops or oral suspensions. This is critical for providing the desired consistency and improving the suspension of insoluble particles.
  • Binder in Tablets: Moderate viscosity grades are often used as binders in tablet manufacturing. They provide the necessary cohesion to form robust tablets that can withstand handling and compression, while also ensuring proper disintegration.
  • Controlled Release Matrix: For sustained-release tablets, higher viscosity grades (like K4m or K100m) are essential. They form a strong gel layer upon contact with moisture in the GI tract, which significantly slows down the diffusion of the API, thereby extending its release time.
  • Film Coating: Lower to medium viscosity grades are typically preferred for tablet film coating. They allow for easy spraying and form uniform, flexible films that enhance the appearance and stability of the tablets.

Navigating HPMC Grade Designations:

When you plan to buy Hypromellose, you will encounter various grade designations. For instance:

  • E-Series (e.g., E5, E6, E15, E50): Generally represent lower to medium viscosity grades, commonly used for film coating, tablet binding, and ophthalmic applications.
  • K-Series (e.g., K4m, K100m): Indicate higher viscosity grades, predominantly used for sustained-release applications due to their superior gel-forming and diffusion-controlling capabilities. The 'm' often denotes a specific molecular weight range or substitution pattern that confers these properties.

NINGBO INNO PHARMCHEM CO.,LTD. offers a comprehensive range of Hypromellose products with clearly defined viscosity specifications. As a reliable pharmaceutical intermediate supplier and manufacturer, we guide our clients in selecting the optimal viscosity grade to achieve their formulation goals. We encourage all prospective buyers to consult our technical specifications and reach out to our team for personalized recommendations when you need to buy pharmaceutical-grade HPMC.