In the meticulous world of pharmaceutical manufacturing, the purity of every raw material and intermediate is not just a desirable trait but an absolute necessity. Amidinothiourea, designated by its CAS number 2114-02-5, is a prime example where purity is paramount, especially given its role as a key intermediate in the synthesis of Famotidine. From the perspective of pharmaceutical development and production, understanding and ensuring the high purity of Amidinothiourea is a critical factor for success.

Amidinothiourea, typically supplied as a white to off-white powder, must meet stringent quality standards to be suitable for pharmaceutical use. The most critical specification is its assay, which for Famotidine synthesis, is typically required to be ≥98.0%. This high level of purity ensures that the subsequent chemical reactions proceed efficiently and that the final active pharmaceutical ingredient (API) is free from contaminants that could compromise its efficacy or safety. Impurities in Amidinothiourea could lead to the formation of unwanted by-products during the synthesis of Famotidine, potentially requiring extensive purification steps or even rendering the batch unusable.

The chemical and physical properties of Amidinothiourea are well-defined, with a molecular formula of C2H6N4S and a molecular weight of approximately 118.161. Its melting point, around 171-173 °C, and its physical appearance contribute to its handling and processing characteristics. However, it is the assay that truly dictates its suitability for pharmaceutical applications. Pharmaceutical formulators and regulatory bodies place a strong emphasis on the purity profile of intermediates, as this directly influences the quality of the final drug product.

For manufacturers seeking to buy Amidinothiourea, it is imperative to partner with amidinothiourea suppliers and manufacturers who demonstrably uphold these purity standards. When inquiring about amidinothiourea price, buyers should always couple this with requests for detailed specifications and Certificates of Analysis (CoA) that confirm the ≥98.0% assay. Reputable amidinothiourea manufacturers, especially those in regions like China known for their robust chemical production, invest heavily in quality control measures to ensure their products meet global pharmaceutical requirements.

The synthesis of Famotidine is a multi-step process, and the performance of each step is influenced by the quality of its precursors. Using Amidinothiourea (CAS 2114-02-5) that consistently meets the ≥98.0% purity mark simplifies downstream processing, reduces batch-to-batch variability, and ultimately contributes to the reliable production of high-quality Famotidine. This focus on purity is what distinguishes a premium amidinothiourea supplier from a commodity provider.

In conclusion, the purity of Amidinothiourea (CAS 2114-02-5) is not a negotiable aspect when it comes to its use in Famotidine production. Pharmaceutical companies must prioritize sourcing this critical intermediate from manufacturers and suppliers who guarantee a high assay and robust quality control. This commitment to purity is fundamental to ensuring the safety, efficacy, and regulatory compliance of essential medicines worldwide.