Indole-5-carboxylic Acid (CAS: 1670-81-1) is a compound that merits close attention within the realm of organic chemistry and its industrial applications. As a versatile indole derivative, it serves as a fundamental building block for creating more complex molecular structures, particularly within the pharmaceutical and fine chemical sectors. This article aims to provide a comprehensive overview of its key properties and applications, highlighting why sourcing this intermediate from a reliable manufacturer is crucial.

Chemically, Indole-5-carboxylic Acid features an indole ring system substituted with a carboxylic acid group at the 5th position. This functional group imparts specific reactivity, allowing it to participate in a variety of chemical transformations such as esterification, amidation, and decarboxylation, among others. Its structural characteristics make it an excellent starting material for synthesizing bioactive molecules.

Physically, Indole-5-carboxylic Acid is typically presented as a light beige to yellow powder. Its melting point is generally in the range of 208-212 °C, indicating a stable solid form under standard conditions. While specific solubility data can vary, it is often soluble in common organic solvents like DMSO and methanol, which is advantageous for reaction preparation. Its stability under normal temperatures and pressures further enhances its utility in laboratory and industrial settings.

The applications of Indole-5-carboxylic Acid are diverse and impactful:

  • Pharmaceutical Development: It's a key intermediate in the synthesis of various therapeutic agents. For instance, it's used to develop selective D3 dopamine receptor agonists for treating Parkinson's disease and inhibitors for enzymes that contribute to antibiotic resistance.
  • Medicinal Chemistry: Researchers utilize it as a scaffold for designing novel drug candidates, exploring its potential in areas like anticancer agents and inhibitors of specific cellular pathways.
  • Organic Synthesis: Its inherent reactivity and structural features make it a valuable reagent for creating diverse heterocyclic compounds and complex organic molecules for material science and other specialized applications.

For companies looking to procure Indole-5-carboxylic Acid, partnering with a reputable manufacturer and supplier is paramount. NINGBO INNO PHARMCHEM CO.,LTD. is a leading provider of this intermediate from China, ensuring high purity, consistent quality, and competitive pricing. We understand the demands of modern R&D and production, and are committed to supporting your projects with reliable chemical solutions. If you require Indole-5-carboxylic Acid for your synthesis needs, we encourage you to request a quote and sample today.