The global chemical industry thrives on the continuous development and supply of specialized compounds that enable technological advancements. 1H-1,2,4-Triazole-3-thiol, identified by CAS number 3179-31-5, is one such compound, noted for its distinctive chemical structure and its role as a key intermediate in various applications. This article aims to provide a comprehensive overview for B2B professionals, covering its properties, potential synthesis routes, and market dynamics, along with practical advice for procurement.

Chemical Properties and Characterization of 1H-1,2,4-Triazole-3-thiol

1H-1,2,4-Triazole-3-thiol is typically presented as a white to off-white crystalline solid. Its physical characteristics, such as a melting point in the range of 221-224°C and solubility in water (specifically 85g/l at 20°C with a pH of 4.0), are indicative of its chemical nature. The molecular formula C2H3N3S and a molecular weight of 101.13 are fundamental identifiers. Its dual functionality—the triazole ring system and the reactive thiol group—makes it a versatile molecule for chemical modification and integration into larger structures. Understanding these properties is crucial for R&D scientists and formulators when considering its use in new applications or optimizing existing ones.

Synthesis Routes and Industrial Production

While specific synthesis routes are often proprietary, compounds like 1H-1,2,4-Triazole-3-thiol are generally produced through cyclization reactions involving thiosemicarbazide derivatives or similar precursors under specific reaction conditions. Industrial production focuses on achieving high purity and yield efficiently. Manufacturers aim for processes that minimize impurities and comply with environmental standards. For buyers, knowing that the compound is produced on a ton scale by reputable manufacturers suggests a mature and reliable production capability. When you seek to buy this chemical, inquire about the manufacturing standards and quality control measures employed by the supplier.

Applications and Market Demand Drivers

The demand for 1H-1,2,4-Triazole-3-thiol is primarily driven by its applications as a pharmaceutical intermediate, a component in photographic developers, and an anti-rust additive. Its role in pharmaceutical synthesis is particularly significant, enabling the creation of complex molecules for drug development. The continuous growth in the pharmaceutical sector directly influences the market demand for such intermediates. Similarly, its use in specialized industrial applications like anti-corrosion treatments contributes to steady market uptake. Procurement managers should stay informed about these application trends to forecast their sourcing needs effectively.

Sourcing Strategies: Finding the Right Supplier

For businesses looking to source 1H-1,2,4-Triazole-3-thiol, selecting a reliable supplier is key. Leading chemical manufacturers and distributors, especially those based in China, offer this product with a strong emphasis on quality (≥99% assay) and competitive pricing. It is advisable to compare quotes from multiple suppliers, verifying their adherence to quality standards and their ability to provide essential documentation like COAs and SDS. Building a relationship with a trusted supplier ensures not only competitive pricing but also supply chain reliability and responsiveness to your specific requirements. Whether for R&D or large-scale production, strategic sourcing of this vital chemical is essential for success.