N-(3-Hydroxyphenyl)-4-toluidine (CAS 61537-49-3) stands out as a crucial chemical intermediate, predominantly in the pharmaceutical sector. Its utility is deeply rooted in its specific chemical properties, which are critical for successful synthesis, particularly in the production of phentolamine. As a manufacturer or researcher, understanding these properties is key to optimizing synthetic routes and ensuring product quality.

The compound presents as a light gray powder, which offers practical advantages in terms of handling, storage, and precise measurement during chemical processes. This physical state is often preferred in industrial settings for its stability and ease of integration into various reaction setups. The molecular weight of approximately 199.25 g/mol provides a clear stoichiometric basis for chemical reactions, allowing for accurate calculations in batch production.


A defining specification for N-(3-Hydroxyphenyl)-4-toluidine is its assay, typically at a minimum of 99.0%. This high purity is non-negotiable for pharmaceutical applications, as even minor impurities can lead to unwanted side reactions, reduced yields, or contamination of the final drug product. Such purity levels indicate meticulous manufacturing processes and stringent quality control measures employed by reputable suppliers in China.


Furthermore, its density, reported as 1.170 ± 0.06 g/cm³, is another parameter that contributes to its material characterization. While not always directly involved in reaction mechanisms, density is important for bulk handling, transportation, and process engineering calculations. These specifications collectively ensure that N-(3-Hydroxyphenyl)-4-toluidine is a reliable and consistent component in complex pharmaceutical syntheses.


In summary, the chemical and physical properties of N-(3-Hydroxyphenyl)-4-toluidine, including its appearance, molecular weight, high assay purity, and density, are fundamental to its role as a pharmaceutical intermediate. These characteristics enable efficient and reliable synthesis, making it an indispensable compound for manufacturers aiming for high-quality pharmaceutical products.