The landscape of modern chemical synthesis is built upon a foundation of versatile and reliable intermediates. Among these, heterocyclic compounds like pyridine derivatives hold significant importance due to their prevalence in biologically active molecules and advanced materials. 2-Bromo-4-tert-butylpyridine (CAS: 50488-34-1) stands out as a particularly useful compound, offering a combination of reactivity and structural features that make it a sought-after building block for chemists across various disciplines.

Chemical Properties and Reactivity Insights

With the chemical formula C9H12BrN and a molecular weight of 214.10, 2-Bromo-4-tert-butylpyridine is a pyridine ring functionalized with a bromine atom at the second position and a tert-butyl group at the fourth. This specific arrangement dictates its chemical behavior. The bromine atom acts as an excellent leaving group and is highly amenable to nucleophilic substitution and transition-metal catalyzed cross-coupling reactions, such as Suzuki, Sonogashira, and Buchwald-Hartwig aminations. These reactions are fundamental in constructing complex organic frameworks. The tert-butyl group, a bulky alkyl substituent, imparts steric hindrance, which can influence the regioselectivity and stereoselectivity of reactions involving the pyridine ring. This steric effect can be strategically employed to control reaction pathways, leading to desired product isomers.

Physically, it is typically described as a colorless to light yellow liquid or solid, with a boiling point of 243.6°C and a density of 1.293 g/cm³. These properties are important for process chemists when designing reaction conditions and purification methods.

Applications in Organic Chemistry and Beyond

The utility of 2-Bromo-4-tert-butylpyridine spans several areas of chemical synthesis. Its primary role is as an intermediate in the preparation of more complex organic molecules. In the pharmaceutical industry, it serves as a crucial building block for the synthesis of Active Pharmaceutical Ingredients (APIs). Its pyridine core is a common feature in many drug molecules, and the bromine atom provides a convenient point for further functionalization to achieve specific biological activity. For researchers and development teams, the ability to buy high-purity 2-Bromo-4-tert-butylpyridine from reliable manufacturers is paramount for consistent and reproducible results in their synthesis pipelines.

Beyond pharmaceuticals, this compound is valuable in the agrochemical sector for developing new crop protection agents and in materials science for the creation of functional organic materials. Its versatility as a synthon makes it attractive for a broad range of research and development projects.

Procurement: Sourcing from Chinese Manufacturers

When professionals in chemical R&D or purchasing departments need to buy 2-Bromo-4-tert-butylpyridine, they often look to established chemical manufacturing regions. China, with its extensive chemical industry infrastructure, offers a significant number of suppliers. The advantages of sourcing from China include competitive pricing, large-scale production capacities, and a wide availability of intermediates. It is crucial for buyers to partner with manufacturers that adhere to stringent quality control standards, typically offering a purity of 97% or higher, and provide comprehensive technical documentation like Certificates of Analysis. For those who need to purchase this chemical, a thorough evaluation of suppliers is recommended to ensure product quality and supply chain reliability.

In essence, 2-Bromo-4-tert-butylpyridine (CAS 50488-34-1) is a key intermediate that empowers chemists in their pursuit of novel compounds. Its well-defined reactivity and structural features make it indispensable for pharmaceutical, agrochemical, and broader organic synthesis applications. By focusing on quality suppliers and understanding its versatile role, researchers and manufacturers can effectively leverage this important chemical building block.