For R&D scientists and formulation chemists working on novel dermatological treatments, understanding the chemical intermediates involved is crucial. 2-Bromo-5-hydroxybenzaldehyde (CAS 2973-80-0) stands out as a pivotal compound, serving as a direct precursor in the synthesis of Crisaborole. This article delves into its key properties, synthesis pathways, and its significance in pharmaceutical research.

Chemical Profile of 2-Bromo-5-hydroxybenzaldehyde:

2-Bromo-5-hydroxybenzaldehyde is an organic compound with the molecular formula C7H5BrO2 and a molecular weight of approximately 201.02 g/mol. It typically presents as a white to gray or brown solid, with a melting point in the range of 130-135 °C. Its solubility characteristics include good solubility in common organic solvents like chloroform, dichloromethane, and ethyl acetate, which are frequently used in synthesis and purification processes.

Role in Crisaborole Synthesis:

Crisaborole, an important topical medication for inflammatory skin conditions, requires a specific synthetic route. 2-Bromo-5-hydroxybenzaldehyde is a critical intermediate in this process, often introduced early in the synthetic chain. Its functional groups—an aldehyde and a hydroxyl group ortho to a bromine atom on a benzene ring—make it a versatile starting material for various coupling and condensation reactions necessary for building the Crisaborole molecule. The precise positioning of these groups dictates the regioselectivity and efficiency of subsequent synthetic steps.

Synthesis and Manufacturing:

The preparation of 2-Bromo-5-hydroxybenzaldehyde can be achieved through several synthetic routes. One common method involves the bromination of 3-hydroxybenzaldehyde. This process requires careful control of reaction conditions, including temperature, solvent, and the stoichiometry of the brominating agent, to ensure selective bromination at the desired position and minimize the formation of by-products. Subsequent purification steps, such as recrystallization or chromatography, are essential to obtain the high-purity material required for pharmaceutical manufacturing. Researchers looking to purchase this compound can search for '2-bromo-5-hydroxybenzaldehyde CAS 2973-80-0' or 'crisaborole intermediate supplier' to identify reliable sources for bulk or research quantities.

Importance for Pharmaceutical R&D:

For scientists engaged in drug discovery, having access to reliable, high-purity chemical intermediates like 2-Bromo-5-hydroxybenzaldehyde is fundamental. It allows for consistent experimental results and smooth scale-up from laboratory research to pilot production. Companies like NINGBO INNO PHARMCHEM CO.,LTD. serve as key suppliers, offering this compound with guaranteed specifications, supporting the advancement of pharmaceutical research and the development of new treatments. Availability from a dedicated manufacturer ensures a stable supply chain, a critical factor for long-term R&D projects and commercial production.