For pharmaceutical companies and contract research organizations (CROs) involved in the development and manufacturing of advanced therapeutics, sourcing high-quality intermediates is paramount. One such critical compound is Methyl 4-(2-methoxy-2-oxoethyl)-3-nitrobenzoate, identified by CAS number 334952-07-7. This light yellow powder serves as a vital building block in the synthesis of Nintedanib and Nintedanib esylate, two significant pharmaceutical agents. Understanding its properties and the advantages of sourcing it from reputable manufacturers can significantly impact production efficiency and cost-effectiveness.

Methyl 4-(2-methoxy-2-oxoethyl)-3-nitrobenzoate, with the molecular formula C11H11NO6 and a molecular weight of 253.20800, is characterized by its specific chemical structure which lends itself to complex organic synthesis pathways. Its typical appearance as a light yellow powder, along with a purity level of ≥95.0%, as evidenced by test results often confirming around 95.27%, makes it a reliable choice for pharmaceutical applications. This level of purity is crucial for ensuring the efficacy and safety of the final Active Pharmaceutical Ingredient (API).

The primary application for this intermediate lies in its role in the synthesis of Nintedanib (CAS: 656247-17-5) and its esylate salt (CAS: 656247-18-6). Nintedanib is a triple angiokinase inhibitor used in the treatment of idiopathic pulmonary fibrosis (IPF) and certain types of non-small cell lung cancer (NSCLC). The efficient and cost-effective production of Nintedanib hinges on the availability of high-quality intermediates like Methyl 4-(2-methoxy-2-oxoethyl)-3-nitrobenzoate. Therefore, identifying reliable suppliers who can guarantee consistent quality and timely delivery is a strategic imperative for any pharmaceutical manufacturer looking to purchase this chemical.

When seeking to buy Methyl 4-(2-methoxy-2-oxoethyl)-3-nitrobenzoate, potential buyers should consider several factors. Firstly, the purity specification is critical; a minimum of 95.0% is generally required, with suppliers demonstrating actual test results to validate this. Secondly, the origin of the supplier is important. Manufacturers and suppliers based in China, such as NINGBO INNO PHARMCHEM CO.,LTD., often offer competitive pricing due to economies of scale and established supply chains for fine chemicals. Engaging with a Chinese manufacturer can provide significant cost advantages without compromising on quality, especially when rigorous quality control measures are in place.

Furthermore, understanding the packaging and storage requirements is essential. This intermediate is typically supplied in 25kg cardboard drums or as per customer-specified requirements, and it should be stored in a cool, dry, well-closed container, away from moisture and strong light/heat. Such conditions ensure the compound's stability and prolong its shelf life. For businesses looking to purchase this compound, inquiring about the availability of technical data sheets (TDS), Certificates of Analysis (CoA), and Material Safety Data Sheets (MSDS) is standard practice to ensure all necessary documentation is readily available.

In conclusion, Methyl 4-(2-methoxy-2-oxoethyl)-3-nitrobenzoate (CAS 334952-07-7) is an indispensable intermediate for the pharmaceutical industry, particularly for Nintedanib synthesis. By partnering with experienced manufacturers and suppliers, such as those in China, companies can secure a reliable supply of this high-purity chemical at competitive prices. This strategic sourcing approach ensures the uninterrupted production of life-saving medications, underscoring the importance of robust chemical supply chains in modern healthcare.