The development and manufacturing of pharmaceutical drugs rely heavily on a robust supply chain of high-quality chemical intermediates. Diuretics, a class of drugs vital for managing fluid balance in conditions like hypertension and heart failure, are no exception. Among these, Torasemide is a widely prescribed loop diuretic. Its synthesis involves several key intermediates, with 4-(3-Methylphenyl)amino-3-pyridinesulfonamide (CAS 72811-73-5) standing out as a pivotal component. For pharmaceutical R&D scientists and procurement managers, understanding these intermediates and their suppliers is crucial.

Torasemide's therapeutic action stems from its ability to inhibit the sodium-potassium-chloride cotransporter in the thick ascending limb of the loop of Henle, leading to increased excretion of sodium, chloride, and water. The chemical structure of Torasemide is complex, and its efficient synthesis requires precise manipulation of precursor molecules. 4-(3-Methylphenyl)amino-3-pyridinesulfonamide serves as a foundational building block in this synthetic pathway. Its chemical properties, such as its high purity (≥99.0%) and stable crystalline powder form, make it an ideal starting material for pharmaceutical synthesis.

When pharmaceutical companies look to buy this crucial intermediate, they are seeking a reliable supplier that can consistently deliver material meeting stringent specifications. Factors such as appearance (white to off-white crystalline powder), low moisture content, and minimal individual impurities are critical. The price of this intermediate will vary based on purity, quantity, and the supplier's origin. Sourcing from a direct manufacturer in China, like NINGBO INNO PHARMCHEM CO.,LTD., can offer significant advantages in terms of both cost and supply chain control.

The synthesis of Torasemide typically involves reacting 4-(3-Methylphenyl)amino-3-pyridinesulfonamide with an appropriate reagent to introduce the sulfonylurea moiety, which is characteristic of Torasemide. The quality of 4-(3-Methylphenyl)amino-3-pyridinesulfonamide directly influences the yield and purity of the final Torasemide API. Therefore, selecting a supplier with a strong quality management system is paramount.

Procurement managers and R&D teams often need to obtain a detailed quote and product specifications before committing to a purchase. This allows for thorough evaluation and comparison of different suppliers. For those working on Torasemide production or related research, establishing a relationship with a dependable source for CAS 72811-73-5 is a strategic necessity. The ability to rely on a supplier for consistent quality and timely delivery ensures uninterrupted production schedules.

In conclusion, 4-(3-Methylphenyl)amino-3-pyridinesulfonamide (CAS 72811-73-5) is an indispensable intermediate in the manufacturing of Torasemide. Its importance highlights the critical role of specialized chemical suppliers in the pharmaceutical industry. By focusing on high-purity materials from trustworthy manufacturers, pharmaceutical companies can ensure the successful production of effective and safe diuretic medications.