The synthesis of Lercanidipine hydrochloride, a widely prescribed calcium channel blocker for hypertension, depends critically on the availability of high-quality pharmaceutical intermediates. Among these, 5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid (CAS 74936-72-4) is a pivotal compound. Pharmaceutical companies seeking to buy this intermediate must prioritize purity, reliability, and competitive sourcing to ensure efficient drug production.

Lercanidipine is a potent antihypertensive agent, and its therapeutic effectiveness is directly linked to the precision of its chemical structure. The synthesis pathway involves several steps, with this specific dihydropyridine derivative serving as a crucial precursor. The quality of this intermediate profoundly impacts the yield and purity of the final API, making its selection a strategic decision for any pharmaceutical manufacturer.

The Importance of Purity and Specifications

When you purchase 5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid, ensuring it meets stringent quality standards is paramount. Typically, a purity of ≥98.0% is expected. This high purity minimizes side reactions during subsequent synthesis steps and ensures the final Lercanidipine API meets regulatory requirements. Buyers should always verify that the supplier can provide detailed analytical data and a Certificate of Analysis (CoA) confirming these specifications.

Finding Reliable Suppliers and Manufacturers

Identifying a trustworthy manufacturer or supplier for this critical intermediate is essential for consistent production. Key considerations include:

  • Manufacturing Expertise: Partner with companies that specialize in complex organic synthesis and have a proven track record in producing pharmaceutical intermediates.
  • Quality Management Systems: Look for suppliers with robust ISO or GMP certifications, demonstrating a commitment to quality.
  • Supply Chain Stability: Ensure the supplier has adequate production capacity and a reliable logistics network to meet your volume requirements and delivery timelines.
  • Competitive Pricing: Obtain quotes from multiple sources to secure the best possible price for Lercanidipine synthesis intermediate, especially for bulk orders.

The global market offers numerous options, but a direct approach to manufacturers, particularly those based in regions with strong chemical production capabilities like China, can often yield the best results in terms of both quality and cost. When you buy intermediates, remember that the investment in a high-quality, reliable source pays dividends in the long run.

We are dedicated to providing high-purity pharmaceutical intermediates and building strong partnerships with our clients. Connect with us to learn more about our offerings and how we can support your Lercanidipine hydrochloride manufacturing needs.