In the complex landscape of pharmaceutical manufacturing, identifying and sourcing reliable chemical intermediates is a cornerstone of successful drug development. Sodium 1-(2-hydroxyethyl)-1H-tetrazol-5-ylthiolate, with the CAS number 64350-77-2, is one such intermediate that plays a crucial role in various synthetic pathways.

Chemical Identity and Properties

Sodium 1-(2-hydroxyethyl)-1H-tetrazol-5-ylthiolate is a chemical compound identified by its CAS Registry Number 64350-77-2. Its molecular formula is C3H5N4OS·Na. A key characteristic highlighted by suppliers is its appearance: typically a white to off-white crystalline powder. This physical form is standard for many fine chemical intermediates, facilitating handling and integration into various synthesis processes.

The compound's chemical structure, featuring a tetrazole ring and a thiolate group, makes it a valuable building block. These functional groups are often sought after in medicinal chemistry for their ability to influence the pharmacological properties of drug molecules, such as receptor binding, solubility, or metabolic stability.

Role as a Pharmaceutical Intermediate

The primary application of Sodium 1-(2-hydroxyethyl)-1H-tetrazol-5-ylthiolate is as an intermediate in the synthesis of Active Pharmaceutical Ingredients (APIs). Pharmaceutical companies utilize such intermediates in multi-step reaction sequences to construct complex drug molecules. The high purity, often specified as ≥99%, is critical because even small amounts of impurities in an intermediate can significantly impact the yield, purity, and efficacy of the final API, potentially leading to batch failures or regulatory issues.

When researchers or procurement specialists look to buy this compound, they are typically engaged in the development or manufacturing of specific therapeutic agents where this particular chemical structure is required.

Sourcing and Purchasing Considerations

For those needing to buy Sodium 1-(2-hydroxyethyl)-1H-tetrazol-5-ylthiolate, partnering with reliable manufacturers and suppliers is essential. Key considerations include:

  • Purity and Specifications: Always verify the product's assay and ensure it meets your project's specific requirements.
  • Supplier Reliability: Choose manufacturers with a strong reputation for quality and consistent supply. Companies operating in China are often significant global suppliers for such intermediates.
  • Documentation: Ensure that comprehensive documentation, including a Certificate of Analysis (CoA) and Safety Data Sheet (SDS), is readily available.
  • Price and Lead Time: Obtain quotes from multiple suppliers and inquire about lead times for delivery, especially for larger quantities.

Sodium 1-(2-hydroxyethyl)-1H-tetrazol-5-ylthiolate, CAS 64350-77-2, remains a significant intermediate in the pharmaceutical sector. By focusing on quality, reliability, and strategic sourcing, companies can ensure the successful advancement of their drug development pipelines.