For any successful chemical synthesis, a thorough understanding of the starting materials is fundamental. 11α-Hydroxyprogesterone (CAS 80-75-1) is a vital steroid intermediate, and its specific properties dictate its utility in various pharmaceutical and biochemical applications. This article outlines the key characteristics of this compound, providing essential information for researchers and chemical engineers who are looking to buy this product.

Understanding the Chemical Identity

11α-Hydroxyprogesterone, with the molecular formula C21H30O3 and a molecular weight of approximately 330.46 g/mol, is a hydroxylated derivative of progesterone. Its defining feature is the hydroxyl group positioned at the C11-alpha position of the steroid nucleus. This structural detail is critical for its specific reactivity and biological interactions.

Physical and Chemical Properties: What You Need to Know

  • Appearance: Typically supplied as a white to light beige crystalline powder. The visual consistency is often an initial indicator of purity and proper handling.
  • Purity: Pharmaceutical-grade 11α-Hydroxyprogesterone commonly boasts a purity of 99%, as confirmed by analytical techniques like Gas Chromatography (GC). High purity is essential to avoid side reactions and ensure the efficacy of the final synthesized product.
  • Melting Point: The melting point is an important physical parameter, usually falling within a specific range (e.g., 164-166°C). Deviations can indicate impurities.
  • Solubility: Information on its solubility in various organic solvents and water is crucial for designing reaction conditions and purification protocols.
  • Molecular Structure: The detailed molecular structure, often provided with CAS registration, clarifies the stereochemistry and functional groups, which is vital for computational chemistry and reaction planning.

Applications in Synthesis and Research

The unique properties of 11α-Hydroxyprogesterone make it a sought-after intermediate in several areas:

  • Synthesis of Steroid Hormones: It serves as a key intermediate in the complex synthesis pathways for various corticosteroids and other steroid-based drugs.
  • Endocrine and Biochemical Research: Its structural similarity to endogenous hormones makes it valuable for studying hormonal mechanisms, enzyme activity, and receptor binding in biological systems.
  • Drug Discovery: Researchers use it as a scaffold for developing new therapeutic agents with specific hormonal or metabolic effects.

Reliable Sourcing from Manufacturers

When procuring 11α-Hydroxyprogesterone (CAS 80-75-1), engaging with a reputable manufacturer is key to ensuring you receive material with consistent properties and guaranteed purity. We, as a dedicated chemical supplier in China, specialize in providing high-quality pharmaceutical intermediates. Our commitment to quality control ensures that the 11α-Hydroxyprogesterone you buy from us meets all necessary specifications for your synthesis needs. We encourage you to reach out for detailed product specifications and competitive quotes to facilitate your procurement process.

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