Cyclobutanecarboxylic acid, identified by CAS number 3721-95-7, is a fundamental organic compound with the molecular formula C5H8O2 and a molar mass of 100.12 g/mol. This colorless to slightly amber liquid is highly valued in the chemical industry, particularly for its utility in advanced organic synthesis and pharmaceutical development. As a manufacturer committed to quality, NINGBO INNO PHARMCHEM CO.,LTD. provides this essential intermediate to meet global demand.

Understanding the physical and chemical properties of cyclobutanecarboxylic acid is crucial for its effective application. It exhibits a low melting point of -7.5°C and a boiling point of 195°C, with a density of 1.047 g/mL at 25°C. Its refractive index is n20/D 1.444. While sparingly soluble in water, it dissolves readily in common organic solvents like methanol and chloroform, facilitating its use in various reaction media. Its acidic nature is quantified by a pKa of 4.785 at 25°C.

The synthesis of cyclobutanecarboxylic acid primarily involves the decarboxylation of 1,1-cyclobutanedicarboxylic acid. This process typically occurs when the precursor is heated to approximately 160°C, leading to the release of carbon dioxide. Subsequent distillation yields the desired product with reported yields ranging from 86% to 91%. Another noted synthesis pathway includes the hydrolysis and decarboxylation of diethyl cyclobutanedicarboxylate. For procurement, sourcing from a reliable cyclobutanecarboxylic acid manufacturer in China like NINGBO INNO PHARMCHEM CO.,LTD. ensures product consistency and competitive pricing. If you are looking to buy cyclobutanecarboxylic acid, consider our specialized offerings.