In the realm of organic chemistry and pharmaceutical development, understanding the intrinsic properties and potential applications of key intermediates is vital. 4-(Methylsulfonyl)benzyl Chloride, identified by CAS number 40517-43-9, is one such compound that holds significant value. As a versatile chemical building block, its unique structural features lend themselves to a variety of synthetic processes, particularly in the pharmaceutical sector. This article aims to provide a concise overview of its essential properties and prevalent applications.

Chemical Identity and Properties:

  • CAS Number: 40517-43-9
  • Molecular Formula: C8H9ClO2S
  • Molecular Weight: 204.67 g/mol
  • Appearance: Typically a white solid.
  • Melting Point: Ranges between 78-80°C, indicating good purity for standard grades.
  • Purity: Commonly available at 97%+ purity, essential for sensitive syntheses.
  • Stability: Generally stable under normal atmospheric conditions, but often recommended for refrigerated storage to maintain optimal quality.

The presence of both a reactive benzyl chloride group and an electron-withdrawing methylsulfonyl group makes 4-(Methylsulfonyl)benzyl Chloride a powerful intermediate. The benzyl chloride moiety readily participates in nucleophilic substitution reactions, enabling the introduction of this sulfone-containing benzyl group into various molecular frameworks. This reactivity is central to its utility in constructing complex organic molecules.

Key Applications:

The primary application domain for 4-(Methylsulfonyl)benzyl Chloride is within the pharmaceutical industry. It serves as a crucial intermediate in the synthesis of Active Pharmaceutical Ingredients (APIs). Researchers and manufacturers utilize it to introduce specific structural features that contribute to the pharmacological activity of drug candidates. Its ability to undergo various coupling and substitution reactions makes it a flexible component in multi-step synthetic pathways.

Beyond pharmaceuticals, this compound also finds utility in organic synthesis research and the development of specialty chemicals. Its unique chemical structure can be leveraged to create novel materials or other fine chemicals with specific properties for diverse industrial applications.

When sourcing 4-(Methylsulfonyl)benzyl Chloride, it is imperative to partner with reliable manufacturers and suppliers. Companies committed to high purity standards (97%+) and consistent quality control, often based in China, are key to successful procurement. Whether you are looking to buy for R&D purposes or for large-scale manufacturing, understanding these properties and applications will guide your selection process and ensure you obtain a high-quality intermediate that meets your project’s demands.