In the complex landscape of pharmaceutical synthesis, understanding the role and specifications of key intermediates is crucial for efficient R&D and manufacturing. Methyl 2-acetamido-3-chloro-L-propionate, also known by its CAS number 87333-22-0, is a significant chemical precursor, primarily employed in the production of Ramipril, a widely recognized ACE inhibitor. This article aims to provide a comprehensive overview of this intermediate, its importance, and how to source it effectively.

Properties and Specifications of Methyl 2-acetamido-3-chloro-L-propionate

This compound typically presents as a white to off-white crystalline powder, a visual indicator of its expected high purity. With a molecular formula of C6H10ClNO4, its chemical structure is specifically tailored to facilitate the synthesis of Ramipril. A guaranteed assay of ≥98.0% is a common specification, ensuring that the intermediate is suitable for demanding pharmaceutical applications. The compound's physical and chemical properties, such as solubility and stability, are well-documented, aiding researchers and production teams in process design and optimization.

Sourcing Strategies: Finding the Right Manufacturer

For procurement professionals aiming to buy Methyl 2-acetamido-3-chloro-L-propionate, identifying reliable manufacturers and suppliers is a primary concern. The global market offers various options, but specializing in high-quality pharmaceutical intermediates is key. Many companies, particularly in China, have developed expertise in producing these complex molecules. When searching for a supplier, consider those who offer:

  • Consistent Quality Control: Manufacturers with ISO certifications or adherence to GMP guidelines often provide a higher degree of confidence in product quality.
  • Bulk Supply Capabilities: For commercial production, ensuring a supplier can meet large-volume demands is critical.
  • Competitive Pricing: Access to cost-effective sourcing, especially from established manufacturers in Asia, can significantly impact overall production costs.
  • Technical Support and Documentation: Availability of Certificates of Analysis (CoA), Material Safety Data Sheets (MSDS), and technical support for product application.

Engaging with experienced suppliers ensures that you not only acquire the necessary chemical but also benefit from their expertise in handling, packaging, and logistics, guaranteeing the product's integrity from the manufacturing site to your facility.

The Value Proposition for Pharmaceutical Companies

By securing a dependable source for Methyl 2-acetamido-3-chloro-L-propionate, pharmaceutical companies can streamline their Ramipril production processes. High-purity intermediates reduce the likelihood of side reactions, improve overall yield, and simplify purification steps, ultimately contributing to cost savings and faster time-to-market. Partnering with a qualified supplier is not just about purchasing a chemical; it's about establishing a robust link in the pharmaceutical value chain.